de Luis Daniel Antonio, Pacheco David, Aller Rocío, Izaola Olatz, Bachiller Rosario
Center of Investigation of Endocrinology and Nutrition. Medicine School. Svo de Endocrinología y Nutrición. Hospital Clinico Universitario. University of Valladolid. Valladolid Spain..
Nutr Hosp. 2014 Apr 1;29(4):889-93. doi: 10.3305/nh.2014.29.4.7218.
Studies of the GLP-1 receptor have been directed at identifying polymorphisms in the GLP-1 receptor gene that may be a contributing factor in the pathogenesis of diabetes mellitus and cardiovascular risk factors. Nevertheless, the role of GLP-1 variants on body weight, cardiovascular risk factors and adipokines remains unclear in obese patients.
Our aim was to analyze the effects of rs6923761 GLP-1 receptor polymorphism on body weight, cardiovascular risk factors and serum adipokine levels in morbid obese patients.
A sample of 175 morbid obese patients was enrolled in a prospective way. Basal fasting glucose, c-reactive protein (CRP), insulin, insulin resistance (HOMA), total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides concentration and adipokines were measured. Weights, body mass index, waist circumference, fat mass by bioimpedance and blood pressure measures were measured.
87 patients (49,7%) had genotype GG and 88 (50,3%) had; GA (71 patients, 40,6%) or AA (17 patients, 9,7%) (second group). In the group with GG genotype, levels of glucose (4,4 ± 2,3 mg/dl, p < 0,05), tryglicerides (6,8 ± 4,3 mg/dl , p < 0,05), insulin (4,5 ± 2,3 UI/l , p < 0,05) and HOMA (1,5 ± 0,9 units, p < 0,05) were higher than mutant group. No differences were detected in other parameters.
Data from our study revealed an association with metabolic parameters and rs6923761. Levels of triglycerides, insulin and HOMA were higher in subjects with A alelle than non A allele subjects.
对胰高血糖素样肽-1（GLP-1）受体的研究一直致力于确定GLP-1受体基因中的多态性，这些多态性可能是糖尿病发病机制和心血管危险因素的一个促成因素。然而，在肥胖患者中，GLP-1变体对体重、心血管危险因素和脂肪因子的作用仍不清楚。
我们的目的是分析rs6923761 GLP-1受体多态性对病态肥胖患者体重、心血管危险因素和血清脂肪因子水平的影响。
前瞻性纳入175例病态肥胖患者样本。测量基础空腹血糖、C反应蛋白（CRP）、胰岛素、胰岛素抵抗（HOMA）、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯浓度和脂肪因子。测量体重、体重指数、腰围、生物电阻抗法测定的脂肪量和血压。
87例患者（49.7%）基因型为GG，88例（50.3%）为GA（71例，40.6%）或AA（17例，9.7%）（第二组）。在GG基因型组中，血糖（4.4±2.3mg/dl，p<0.05）、甘油三酯（6.8±4.3mg/dl，p<0.05）、胰岛素（4.5±2.3UI/l，p<0.05）和HOMA（1.5±0.9单位，p<0.05）水平高于突变组。其他参数未检测到差异。
我们的研究数据揭示了rs6923761与代谢参数之间的关联。携带A等位基因的受试者的甘油三酯、胰岛素和HOMA水平高于非A等位基因受试者。
