Chinyere Ikeotunye Royal, Moukabary Talal, Goldman Steven, Juneman Elizabeth
Sarver Heart Center, University of Arizona, Tucson, AZ, United States.
Carondelet Heart and Vascular Institute, Tucson, AZ, United States.
J Electrocardiol. 2018 Jan-Feb;51(1):33-37. doi: 10.1016/j.jelectrocard.2017.09.002. Epub 2017 Sep 23.
A chronic heart failure (CHF) rat underwent epicardial programmed electrical stimulation (PES). Ventricular tachycardia (VT) developed during PES. Mechanical alternans was noted despite fixed tachycardia cycle length. Anti-tachycardia pacing attempts initiated a second VT that generated pulse intermittently and then degenerated into pulseless VT with electrical alternans.To our knowledge electrical and mechanical alternans have not been recorded in animal models of CHF during VT. The distinct events of mechanical alternans and electrical alternans may be indicative of progressively worsened calcium handling in the compromised cardiomyocytes.Although ion channel differences between rodents and humans exist, this work attempts to demonstrate this rat model's usefulness in understanding cardiac electrophysiology in CHF.
一只慢性心力衰竭（CHF）大鼠接受了心外膜程控电刺激（PES）。在PES期间出现了室性心动过速（VT）。尽管心动过速周期长度固定，但仍观察到机械交替。抗心动过速起搏尝试引发了第二种VT，该VT间歇性产生脉冲，然后退化为伴有电交替的无脉VT。据我们所知，在CHF动物模型的VT期间尚未记录到电交替和机械交替。机械交替和电交替的不同事件可能表明受损心肌细胞中钙处理逐渐恶化。尽管啮齿动物和人类之间存在离子通道差异，但这项工作试图证明该大鼠模型在理解CHF心脏电生理方面的有用性。
