Hong Won Gi, Ko Young San, Pyo Jung-Soo
Eulji University School of Medicine, Daejeon 34824, Republic of Korea.
Department of Forensic Medicine, National Forensic Service Busan Institute, Yangsan 50612, Republic of Korea.
Pathol Res Pract. 2017 Dec;213(12):1459-1463. doi: 10.1016/j.prp.2017.11.001. Epub 2017 Nov 8.
The aim of this study was to elucidate the clinicopathological significance and prognostic role of microvessel density (MVD) in gastric cancer (GC) through a meta-analysis.
This meta-analysis included 4094 patients from 26 eligible studies. We investigated the correlation between MVD and clinicopathological characteristics, including survival rate. In addition, subgroup analysis based on microscopic magnification among evaluation criteria of MVD was performed.
High MVD was significantly correlated with worse overall and disease-free survival rates [hazard ratio (HR), 3.028, 95% confidence interval (CI) 2.105-4.357 and HR 2.045, 95% CI 1.530-2.732, respectively]. MVD was significantly increased in GC with diffuse type of Lauren's classification [mean difference (MD) 3.091, 95% CI 0.615-5.567], lymphatic invasion (MD 8.262, 95% CI 3.310-13.214), lymph node metastasis (MD 5.730, 95% CI 2.444-9.016), higher pT stage (pT3-4) (MD 7.093, 95% CI 0.060-14.126) and higher pTNM stage (III-IV) (MD 3.023, 95% CI 0.181-5.865). However, MD of MVD was not significantly different in regard to vascular invasion (MD 7.430, 95% CI 1.015-15.875), tumor differentiation (MD 5.501, 95% CI 1.353-12.355) and tumor size (MD 4.731, 95% CI 2.003-11.465).
Taken together, higher MVD was significantly correlated with worse prognosis. In addition, MVD was significantly higher in GC with aggressive tumor behavior than in GC without aggressive features.
本研究旨在通过荟萃分析阐明微血管密度（MVD）在胃癌（GC）中的临床病理意义及预后作用。
该荟萃分析纳入了来自26项符合条件研究的4094例患者。我们研究了MVD与临床病理特征（包括生存率）之间的相关性。此外，还基于MVD评估标准中的显微镜放大倍数进行了亚组分析。
高MVD与较差的总生存率和无病生存率显著相关[风险比（HR）分别为3.028，95%置信区间（CI）2.105 - 4.357和HR 2.045，95% CI 1.530 - 2.732]。在Lauren分类的弥漫型GC中，MVD显著升高[平均差（MD）3.091，95% CI 0.615 - 5.567]，在有淋巴侵犯（MD 8.262，95% CI 3.310 - 13.214）、淋巴结转移（MD 5.730，95% CI 2.444 - 9.016）、较高的pT分期（pT3 - 4）（MD 7.093，95% CI 0.060 - 14.126）和较高的pTNM分期（III - IV）（MD 3.023，95% CI 0.181 - 5.865）的GC中MVD也显著升高。然而，在血管侵犯（MD 7.430，95% CI 1.015 - 15.875）、肿瘤分化（MD 5.501，95% CI 1.353 - 12.355）和肿瘤大小（MD 4.731，95% CI 2.003 - 11.465）方面，MVD的MD无显著差异。
综上所述，较高的MVD与较差的预后显著相关。此外，具有侵袭性肿瘤行为的GC中的MVD显著高于无侵袭性特征的GC。
