Perivoliotis Konstantinos, Samara Athina A, Koutoukoglou Prodromos, Ntellas Panagiotis, Dadouli Katerina, Sotiriou Sotirios, Ioannou Maria, Tepetes Konstantinos
Department of Surgery, University Hospital of Larissa, Larissa 41110, Greece.
Postgraduate Programme Research Methodology in Biomedicine, Biostatistics and Clinical Bioinformatics, University of Thessaly, Larissa 41110, Greece.
World J Methodol. 2022 Sep 20;12(5):448-458. doi: 10.5662/wjm.v12.i5.448.
Microvessel density (MVD) has been proposed as a direct quantification method of tumor neovascularization. However, the current literature regarding the role of MVD in differentiated thyroid carcinoma (DTC) remains inconclusive.
To appraise the effect of tumoral MVD on the survival of patients with DTC.
This meta-analysis was based on the PRISMA guidelines and the Cochrane Handbook for Systematic Reviews of Interventions. The electronic databases Medline, Web of Science, and Scopus were systematically screened. A fixed-effects or random-effects model was used, according to the Cochran test. The data were then extracted and assessed on the basis of the (https://www.referencecitationanalysis.com/).
A total of nine studies were included in the present study. Superiority of low MVD tumors in terms of 10-year disease free survival (OR: 0.21, 95%CI: 0.08-0.53) was recorded. Lowly vascularized thyroid cancers had a lower recurrence rate (OR: 13.66, 95%CI: 3.03-61.48). Moreover, relapsing tumors [weighed mean difference (WMD): 11.92, 95%CI: 6.32-17.52] or malignancies with regional lymph node involvement (WMD: 8.53, 95%CI: 0.04-17.02) presented with higher tumoral MVD values.
MVD significantly correlates with the survival outcomes of thyroid cancer patients. However, considering several study limitations, further prospective studies of higher methodological and quality level are required.
微血管密度（MVD）已被提议作为肿瘤新生血管形成的直接量化方法。然而，目前关于MVD在分化型甲状腺癌（DTC）中作用的文献尚无定论。
评估肿瘤MVD对DTC患者生存的影响。
本荟萃分析基于PRISMA指南和《Cochrane系统评价干预措施手册》。系统筛选了电子数据库Medline、科学网和Scopus。根据Cochran检验，使用固定效应或随机效应模型。然后根据（https://www.referencecitationanalysis.com/）提取并评估数据。
本研究共纳入9项研究。记录到低MVD肿瘤在10年无病生存率方面的优势（OR：0.21，95%CI：0.08 - 0.53）。血管化程度低的甲状腺癌复发率较低（OR：13.66，95%CI：3.03 - 61.48）。此外，复发性肿瘤[加权平均差（WMD）：11.92，95%CI：6.32 - 17.52]或伴有区域淋巴结受累的恶性肿瘤（WMD：8.53，95%CI：0.04 - 17.02）的肿瘤MVD值较高。
MVD与甲状腺癌患者的生存结果显著相关。然而，考虑到多项研究局限性，需要开展更高方法学和质量水平的进一步前瞻性研究。
