Centre de Recherche de l'Institut Universitaire en Santé Mentale de Montréal, Montreal, Canada; Department of Psychiatry, University of Montreal, Montreal, Canada.
Department of Psychiatry, University of Montreal, Montreal, Canada; Department of Psychiatry, Douglas Mental Health University Institute, McGill Group for Suicide Studies, McGill University, Montréal, Canada.
Schizophr Res. 2018 Jul;197:249-252. doi: 10.1016/j.schres.2017.11.011. Epub 2017 Nov 9.
We investigated the influence of anger processing on cognitive control in male schizophrenia patients presenting violent behaviors. We recruited 23 patients without and 24 patients with (SCZ+V) a history of violent behaviors, as well as 22 healthy non-violent men. Participants were administered an affective (angry-neutral faces) Go/NoGo task while undergoing functional magnetic resonance imaging. We found a reduced activation in the dorsolateral prefrontal cortex in SCZ+V patients specifically when inhibiting a response while viewing angry faces. These results show an inability of SCZ+V to recruit a core region of the (inhibitory) cognitive control network in the context of anger.
我们研究了愤怒处理对男性精神分裂症患者暴力行为认知控制的影响。我们招募了 23 名无暴力行为史的患者和 24 名有暴力行为史的患者（SCZ+V），以及 22 名健康的非暴力男性。参与者在进行功能磁共振成像的同时接受了情感（愤怒中性面孔）Go/NoGo 任务。我们发现，在观看愤怒面孔时抑制反应时，SCZ+V 患者的背外侧前额叶皮层的激活减少。这些结果表明，在愤怒的情况下，SCZ+V 无法在认知控制网络（抑制性）的核心区域内招募。
