Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Child Psychiatry, Chang Gung Memorial Hospital at Linkou, Taiwan.
Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.
Prog Neuropsychopharmacol Biol Psychiatry. 2018 Mar 2;82:233-241. doi: 10.1016/j.pnpbp.2017.11.008. Epub 2017 Nov 9.
Although recent studies revealed impaired self-regulation (dysregulation) in autism spectrum disorder (ASD), neural correlates of dysregulation and its impacts on autistic neuroanatomy remain unclear. Voxel-based morphometry was applied on structural MRI images in 81 ASD and 61 typically developing (TD) boys aged 7-17years. Dysregulation was defined by the sum of T-scores of Attention, Aggression, and Anxiety/Depression subscales in the Child Behavior Checklist>180. There were 53 and 28 boys in the ASD+Dysregulation and ASD-Dysregulation groups, respectively. First, we compared regional gray matter (GM) volume for ASD and TD. Second, we investigated regional GM volumetric differences among the ASD+Dysregulation, ASD-Dysregulation and TD groups. Lastly, shared and distinct neurostructural correlates of dysregulation were investigated in the ASD and TD groups. The ASD-TD difference on neuroanatomy no longer existed after controlling the dysregulation severity. ASD+Dysregulation had larger regional GM volumes in the right fusiform gyrus, and smaller GM volumes in the anterior prefrontal cortex than ASD-Dysregulation and TD, respectively. ASD+Dysregulation had smaller GM volumes in the left lateral occipital/superior parietal cortex than TD boys. No GM difference was identified between ASD-Dysregulation and TD. ASD and TD had a shared association between GM volumes in the orbitofrontal cortex and dysregulation levels. Our findings suggest that atypical neuroanatomy associated with ASD might partially reflect a disproportionate level of impaired self-regulation. Categorical and dimensional considerations of dysregulation should be implemented in future ASD studies.
虽然最近的研究揭示了自闭症谱系障碍（ASD）中的自我调节受损（失调），但失调的神经相关性及其对自闭症神经解剖结构的影响仍不清楚。对 81 名 ASD 和 61 名典型发育（TD）男孩的结构 MRI 图像进行了基于体素的形态测量，年龄为 7-17 岁。失调是通过儿童行为检查表中的注意力、攻击和焦虑/抑郁分量表的 T 分数总和来定义的>180。ASD+失调组和 ASD-失调组分别有 53 名和 28 名男孩。首先，我们比较了 ASD 和 TD 的区域性灰质（GM）体积。其次，我们研究了 ASD+失调、ASD-失调和 TD 组之间的区域性 GM 体积差异。最后，在 ASD 和 TD 组中研究了失调的共享和独特神经结构相关性。在控制失调严重程度后，ASD 在神经解剖学上的差异不再存在。与 ASD-Dysregulation 和 TD 相比，ASD+Dysregulation 右侧梭状回的 GM 体积更大，前前额皮质的 GM 体积更小。与 TD 男孩相比，ASD+Dysregulation 的左侧外侧枕叶/顶叶上回 GM 体积较小。ASD-Dysregulation 和 TD 之间没有 GM 差异。ASD 和 TD 之间存在眶额叶皮质 GM 体积与失调水平之间的共同关联。我们的研究结果表明，与 ASD 相关的非典型神经解剖结构可能部分反映了自我调节受损的不成比例水平。在未来的 ASD 研究中，应实施失调的分类和维度考虑。
