Laboratory of Psychophysiology of Individual Differences, Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.
Laboratory of Psychophysiology of Individual Differences, Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia; Humanitarian Institute, Novosibirsk State University, Novosibirsk, Russia.
Neuroscience. 2018 Jan 15;369:139-151. doi: 10.1016/j.neuroscience.2017.11.010. Epub 2017 Nov 10.
A number of studies have shown that the presence of short (S) allele of the serotonin transporter-linked polymorphic region (5-HTTLPR) is associated with a higher risk for depression following exposure to stressful life events. These findings are in line with neuroimaging studies showing that 5-HTTLPR polymorphism has an effect on the connectivity among key areas involved in emotion regulation. Here using mediated moderation analysis, we show that electrophysiological manifestations of resting state networks in the alpha frequency band mediate the effect of 5-HTTLPR by stress interaction on depression/anxiety symptoms in a nonclinical sample. Specifically, at the brain level, both L-allele homozygotes and S-allele carriers are similarly responsive to stress exposure. However, these brain responses seem to act as triggers of psychopathological symptoms in S-allele carriers, but as suppressors in L-allele homozygotes. This finding implies that the interpretation of the effect of gene by environment interaction on psychopathology seems more complicated than behavioral results alone would imply. It is not just differential sensitivity to stress, but rather different ways of coping with stress, which distinguish S-allele carriers and L-allele homozygotes.
许多研究表明，5-羟色胺转运体相关多态性区域（5-HTTLPR）的短（S）等位基因的存在与暴露于应激性生活事件后抑郁的风险增加有关。这些发现与神经影像学研究一致，表明 5-HTTLPR 多态性对参与情绪调节的关键区域之间的连通性有影响。在这里，我们使用中介调节分析表明，在非临床样本中，静息状态网络的 alpha 频带的电生理表现介导了 5-HTTLPR 与应激相互作用对抑郁/焦虑症状的影响。具体来说，在大脑水平上，L 等位基因纯合子和 S 等位基因携带者对暴露于应激的反应相似。然而，这些大脑反应似乎在 S 等位基因携带者中充当精神病理症状的触发因素，但在 L 等位基因纯合子中充当抑制因素。这一发现表明，对基因与环境相互作用对精神病理学影响的解释似乎比单纯的行为结果更为复杂。区分 S 等位基因携带者和 L 等位基因纯合子的不是对压力的敏感性差异，而是应对压力的不同方式。
