Perry David M, Barton Virginia, Alberg Anthony J
Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, SC, United States.
Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, United States.
Curr Dermatol Rep. 2017 Sep;6(3):161-168. doi: 10.1007/s13671-017-0185-6. Epub 2017 May 29.
To provide a synopsis of recent research advances in the epidemiology of keratinocyte carcinoma (KC), with a focus on indoor tanning and known risk factors for other forms of cancer such as cigarette smoking and alcohol drinking.
The evidence is strong enough to infer that use of UVR-emitting indoor tanning devices cause KC. Epidemiologic studies of cigarette smoking, alcohol drinking, and menopausal hormone therapy all show some suggestion for increased risk of KC but the evidence is not yet strong enough to determine if there is a true etiologic role. Body mass index is clearly inversely associated with KC risk but this is more likely to be due to lower UVR exposure in overweight and obese individuals than it is due to a true etiologic role.
The epidemic of KC continues unabated, and the causal role of indoor tanning is contributing to this unfavorable trend in KC incidence rates. Advances in understanding the etiology of KC should not divert attention away from the fact that the primary public health strategy to prevent KC is known: minimize population exposure to UVR from the sun and from UVR-emitting indoor tanning devices, particularly among those with sun-sensitive phenotypes.
概述皮肤角质形成细胞癌（KC）流行病学的最新研究进展，重点关注室内晒黑以及吸烟和饮酒等其他癌症形式的已知风险因素。
有足够的证据推断，使用发射紫外线的室内晒黑设备会导致KC。吸烟、饮酒和绝经后激素治疗的流行病学研究均显示出KC风险增加的一些迹象，但证据尚不足以确定是否存在真正的病因学作用。体重指数与KC风险明显呈负相关，但这更可能是由于超重和肥胖个体的紫外线暴露较低，而非真正的病因学作用。
KC的流行仍在持续，室内晒黑的因果作用导致了KC发病率的这一不利趋势。在了解KC病因方面的进展不应转移人们对以下事实的关注：预防KC的主要公共卫生策略是已知的，即尽量减少人群暴露于来自太阳和发射紫外线的室内晒黑设备的紫外线，特别是在那些具有光敏感表型的人群中。
