Department of Dermatology, Brown Medical School, Providence, Rhode Island, USA.
J Natl Compr Canc Netw. 2010 Aug;8(8):867-72; quiz 873. doi: 10.6004/jnccn.2010.0063.
Recreational indoor tanning with ultraviolet (UV) radiation has become popular in recent decades, particularly among teenagers and young adults. The consequences for public health have become an important area of concern. The link between this form of UV exposure and both melanoma and non-melanoma skin cancers has been clarified through multiple lines of evidence from epidemiology and laboratory science reflected in recent reports by multiple prestigious bodies. Some have suggested that this form of indoor tanning has a role in vitamin D generation, but a review of existing evidence suggests that indoor tanning is neither a reliable nor advisable source. In addition, laboratory data suggest that tanning promotes a common molecular intermediate in skin carcinogenesis, DNA damage, which thus precludes the concept of a "safe tan." Finally, emerging evidence links UV signaling in skin to dependency/addiction, thus having implications for the organic (rather than cosmetic) impact of the process. This article presents the epidemiologic and mechanistic data relevant to the safety considerations for indoor tanning.
近几十年来，人们热衷于在室内进行紫外线（UV）辐射的休闲性日光浴，尤其是青少年和年轻人。这对公众健康造成了严重影响，相关部门对此也愈发关注。从流行病学和实验室科学的多个角度来看，都证明了这种形式的紫外线暴露与黑色素瘤和非黑色素瘤皮肤癌之间存在关联，这一点在多个权威机构最近的报告中也有所体现。有人认为，这种室内晒黑方式在生成维生素 D 方面发挥了作用，但对现有证据的回顾表明，室内晒黑既不是可靠的方法，也不被推荐。此外，实验室数据表明，晒黑会促进皮肤癌发生过程中的一种常见分子中间产物，即 DNA 损伤，这就排除了“安全晒黑”的概念。最后，新出现的证据将皮肤中的 UV 信号与依赖/成瘾联系起来，从而对这一过程的有机（而非美容）影响产生了影响。本文介绍了与室内晒黑安全性考虑相关的流行病学和机制数据。
