Seuter F, Busse W D
Agents Actions Suppl. 1979(4):175-83.
Sodium arachidonate (1.1 mg/kg b.w.) was injected into a marginal ear vein of rabbits according to SILVER M.J. et al. (1). 94% of the animals died within a few minutes. We investigated to what extent these lethal effects of arachidonic acid (possibly caused by embolizing platelet thrombi) can be prevented by potential antithrombotic drugs. As indicated in the tables the animals are protected by some compounds, especially the nonsteroidal anti-inflammatory agents, in a dose-dependent manner. However, the results of this in vivo model showed no correlation with the potency of the drugs for inhibiting platelet aggregation and inhibition of experimental thrombosis. It is therefore reasonable to assume that the drug effects in this model reflect an overall inhibition of prostaglandins including thromboxanes.
按照SILVER M.J.等人（1）的方法，将花生四烯酸钠（1.1毫克/千克体重）注入兔耳边缘静脉。94%的动物在几分钟内死亡。我们研究了潜在的抗血栓药物能在多大程度上预防花生四烯酸的这些致死作用（可能由栓塞性血小板血栓引起）。如表所示，一些化合物，尤其是非甾体抗炎药，以剂量依赖的方式保护动物。然而，该体内模型的结果与药物抑制血小板聚集和实验性血栓形成的效力无关。因此，合理的假设是该模型中的药物作用反映了包括血栓素在内的前列腺素的全面抑制。
