Department of Rehabilitation, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
Department of Locomotive Rehabilitation Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Muscle Nerve. 2018 Apr;57(4):672-678. doi: 10.1002/mus.26011. Epub 2017 Dec 8.
This study investigated longitudinal changes in muscle extension and collagen expression in an immobilized rat soleus muscle, and assessed the relationship between both elements.
Soleus muscles of the control and immobilization groups (1, 2, 4, 8, and 12 weeks) were used for analysis of muscle extensibility and collagen expression.
The slope value/physiological cross-sectional area (PCSA; a parameter for muscle extensibility) and hydroxyproline (a parameter for collagen expression) were significantly higher in the immobilization group than in the control group for all experimental time points. In the immobilization group, both factors were significantly higher at 4, 8, and 12 weeks than at 1 and 2 weeks after immobilization. A significant positive correlation was observed between the slope value/PCSA and hydroxyproline expression.
The present study indicated that a decrease in muscle extensibility depended on collagen overexpression in immobilized rat soleus muscles. Muscle Nerve 57: 672-678, 2018.
本研究旨在探讨固定大鼠比目鱼肌中肌肉伸展性和胶原表达的纵向变化，并评估这两个因素之间的关系。
使用对照组和固定组（1、2、4、8 和 12 周）的比目鱼肌，分析肌肉伸展性和胶原表达。
在所有实验时间点，固定组的斜率值/生理横截面积（PCSA；肌肉伸展性的参数）和羟脯氨酸（胶原表达的参数）均显著高于对照组。在固定组中，与固定后 1 和 2 周相比，4、8 和 12 周时这两个因素均显著升高。斜率值/PCSA 与羟脯氨酸表达之间存在显著的正相关关系。
本研究表明，在固定的大鼠比目鱼肌中，肌肉伸展性的降低取决于胶原的过度表达。肌肉神经 57:672-678,2018。
