Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, People's Republic of China.
Shanghai Diabetes Institute, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
IUBMB Life. 2017 Dec;69(12):947-955. doi: 10.1002/iub.1693. Epub 2017 Nov 11.
The aim of the work was to determine the effect of body fat change on risk of diabetes in normal glucose tolerance (NGT) population. A total of 1,857 NGT subjects were included and followed up for an average period of 44.57 months. Body fat percentage (BF%) was measured by bioelectrical impedance analysis. Subjects were grouped based on the BF% and/or body mass index (BMI) state. Among all subjects, 28 developed diabetes after follow-up. Compared with subjects with stable normal BF% (control), subjects who became obesity at follow-up were defects in insulin secretion and had a higher risk of developing diabetes (7.102, 95% confidence intervals [CI] 1.740-28.993), while no difference in diabetic risk could be viewed between subjects with abnormal BF% at baseline but normal at the end of follow-up and control subjects after adjustment of confounding factors. Moreover, compared with those keeping normal BF% and BMI both at baseline and follow-up, subjects who had normal BMI at baseline and follow-up, but abnormal BF% at baseline or/and follow-up still had a higher risk to develop diabetes (4.790, 95% CI 1.061-21.621), while those with normal BF% at baseline and follow-up, but abnormal BMI at baseline or/and follow-up had not. Subjects from normal BF% at baseline to obese at follow-up are associated with an increased risk of diabetes. Maintaining normal body fat is more relevant than BMI in preventing diabetes. © 2017 IUBMB Life, 69(12):947-955, 2017.
本研究旨在探讨体脂变化对正常血糖耐量（NGT）人群糖尿病发病风险的影响。共纳入 1857 例 NGT 受试者，平均随访 44.57 个月。采用生物电阻抗分析测量体脂百分比（BF%）。根据 BF%和/或体重指数（BMI）状态对受试者进行分组。在所有受试者中，有 28 例在随访后发生糖尿病。与随访期间 BF%稳定正常的受试者（对照组）相比，随访时肥胖的受试者胰岛素分泌受损，发生糖尿病的风险更高（7.102，95%置信区间[CI]1.740-28.993），而在调整混杂因素后，基线 BF%异常但随访期末正常的受试者与对照组之间糖尿病发病风险无差异。此外，与基线和随访时均保持正常 BF%和 BMI 的受试者相比，基线和随访时 BMI 正常但 BF%异常的受试者发生糖尿病的风险更高（4.790，95%CI1.061-21.621），而基线和随访时 BF%正常但 BMI 异常的受试者则无此风险。从基线时的正常 BF%变为随访时的肥胖与糖尿病发病风险增加相关。与 BMI 相比，维持正常体脂在预防糖尿病方面更为重要。©2017 IUBMB Life，69（12）：947-955，2017。
