正常体重中心型肥胖及其对 2 型糖尿病的影响。
Normal Weight Central Obesity and its Impact on Type 2 Diabetes Mellitus.
机构信息
College of Physical Education and Sports, Beijing Normal University, Beijing, 100875, China.
The George Institute for Global Health, University of New South Wales, Sydney, 2050, Australia.
出版信息
Curr Diab Rep. 2024 Nov 6;25(1):3. doi: 10.1007/s11892-024-01559-x.
PURPOSE OF REVIEW
The aim of this review is to provide an updated commentary on the current literature examining the impact of normal weight obesity (NWO) and normal weight central obesity (NWCO) on type 2 diabetes mellitus in adults.
RECENT FINDINGS
Total 14 studies were included, comprising 9 cross-sectional and 5 cohort studies with 334,438 subjects. The quality of evidence was mixed. The pooled prevalence of NWO was 16.1% (95% CI: 12.7-19.4) and NWCO was 21.1% (95% CI: 12.2-30.1). The prevalence of NWO and NWCO higher in females and non-Asians. This review also showed that type 2 diabetes was significantly associated with NWO and NWCO (pooled OR: 1.82 [1.62, 2.04], p < 0.01, I2 = 64%). Subgroup analyses revealed consistent relationships between type 2 diabetes and NWO/NWCO across sex, region and definition approach. There was a relative high prevalence of NWO and NWCO, particularly in females and non-Asian populations. There was a consistent association of NWO/NWCO with type 2 diabetes. Implications for future research to guide intervention optimization in clinical practice and public health promotion are provided.
目的综述
本综述的目的是提供对当前文献的最新评论，这些文献探讨了正常体重肥胖（NWO）和正常体重中心性肥胖（NWCO）对成年人 2 型糖尿病的影响。
最近的发现
共纳入 14 项研究，包括 9 项横断面研究和 5 项队列研究，共 334438 名受试者。证据质量参差不齐。NWO 的总患病率为 16.1%（95%CI：12.7-19.4），NWCO 的患病率为 21.1%（95%CI：12.2-30.1）。女性和非亚洲人群中 NWO 和 NWCO 的患病率较高。本综述还表明，2 型糖尿病与 NWO 和 NWCO 显著相关（合并 OR：1.82[1.62，2.04]，p<0.01，I2=64%）。亚组分析显示，2 型糖尿病与 NWO/NWCO 之间存在一致的关系，无论性别、地区和定义方法如何。NWO 和 NWCO 的患病率相对较高，尤其是在女性和非亚洲人群中。NWO/NWCO 与 2 型糖尿病之间存在一致的关联。本研究为未来的研究提供了指导，以优化临床实践中的干预措施和促进公共卫生。
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