齐多夫定对人类免疫缺陷病毒相关银屑病的抗银屑病作用。

Antipsoriatic effects of zidovudine in human immunodeficiency virus-associated psoriasis.

作者信息

Kaplan M H, Sadick N S, Wieder J, Farber B F, Neidt G W

机构信息

Department of Medicine, Cornell University Medical College, North Shore University Hospital, Manhasset, NY 11030.

出版信息

J Am Acad Dermatol. 1989 Jan;20(1):76-82. doi: 10.1016/s0190-9622(89)70011-6.

DOI:10.1016/s0190-9622(89)70011-6

PMID:2913083

Abstract

Four patients with psoriasis complicating human immunodeficiency virus (HIV) infection showed marked improvement in their psoriasis after being treated with oral zidovudine. The antipsoriatic effect persisted in two patients in spite of worsening helper T cell depletion. The antipsoriatic effect appeared to be dose-dependent and was associated with the development of erythrocyte macrocytosis, a known side effect of zidovudine. Zidovudine is useful for the therapy of HIV-associated psoriasis and should be tested for efficacy in non-HIV-associated psoriasis.

摘要

4例合并人类免疫缺陷病毒（HIV）感染的银屑病患者在接受口服齐多夫定治疗后，银屑病病情显著改善。尽管辅助性T细胞耗竭加重，但仍有2例患者的抗银屑病疗效持续存在。抗银屑病作用似乎呈剂量依赖性，且与齐多夫定已知的副作用红细胞大细胞症的发生有关。齐多夫定对治疗HIV相关银屑病有效，应在非HIV相关银屑病中进行疗效测试。