地西泮对健康年轻志愿者 24 小时血压和心率的影响。

Effect of Diazepam on 24-Hour Blood Pressure and Heart Rate in Healthy Young Volunteers.

机构信息

Interinstitutional Center of Neurological Medicine, IRCCS C. Mondino National Neurological Institute, Pavia, Italy.

Department of Neurosciences and Behaviour, University of Pavia, Pavia, Italy.

出版信息

Pharmacology. 2018;101(1-2):86-91. doi: 10.1159/000481665. Epub 2017 Oct 31.

DOI:10.1159/000481665

PMID:29131129

Abstract

AIM

To assess the effects of evening chronic administration of diazepam on 24-h blood pressure (BP) and heart rate (HR) in healthy young adults.

METHODS

This randomized double blind, cross-over study evaluated the effects of diazepam 5 mg or placebo, both ingested in the evening, on 24-h ambulatory BP and HR in healthy subjects aged 21-30.

RESULTS

A total of 30 subjects were included in the analysis. At the end of 4-week diazepam intake, an increase in 24-h HR mean values was found (+5.2 beats/min, p < 0.05). Analysis of subperiods showed that diazepam produced a 10.1% increase in night-time HR (+6.1 beats/min, p < 0.01) without affecting BP. A significant HR rise (+4.9 beats/min, p < 0.05) and SBP reduction (-3.8 mm Hg, p < 0.05) were observed in the morning hours. The HR increase persisted in day-time hours (+4.6 beats/min, p < 0.05), while BP values resulted unaffected.

CONCLUSIONS

In healthy subjects, diazepam taken as a hypnotic agent induces a significant HR increase, possibly mediated by a decrease in vagal tone. This effect might be of clinical relevance due to the role that HR plays as an independent cardiovascular risk factor.

摘要

目的

评估在健康年轻成年人中，晚上慢性给予地西泮对 24 小时血压（BP）和心率（HR）的影响。

方法

这项随机、双盲、交叉研究评估了地西泮 5mg 或安慰剂在晚上服用对 21-30 岁健康受试者 24 小时动态血压和 HR 的影响。

结果

共有 30 名受试者纳入分析。在 4 周地西泮摄入结束时，发现 24 小时 HR 均值增加（+5.2 次/分钟，p < 0.05）。亚时段分析显示，地西泮使夜间 HR 增加了 10.1%（+6.1 次/分钟，p < 0.01），而不影响 BP。在早晨观察到 HR 明显升高（+4.9 次/分钟，p < 0.05）和 SBP 降低（-3.8 毫米汞柱，p < 0.05）。在白天，HR 升高持续（+4.6 次/分钟，p < 0.05），而 BP 值不受影响。