Department of ENT and Department of Oncology; Hebei General Hospital, Shijiazhuang City, China.
Eur Rev Med Pharmacol Sci. 2017 Oct;21(20):4591-4594.
To investigate the expression of OCT4 and its clinical significance in laryngeal squamous carcinoma tissues.
Immunohistochemical staining was used to analyze the expression of OCT4 in 61 cases of laryngeal squamous carcinoma and 10 cases of the adjacent normal laryngeal tissues.
The expression of OCT4 was not detected in normal laryngeal tissues, but could be detected in the nucleus of laryngeal carcinoma. The positive expression rates of OCT4 in well-moderately differentiated and poorly differentiated laryngeal squamous carcinoma tissues were 25.6% (11/43) and 66.7% (12/18) respectively, and there were significant differences (p < 0.01). The expression of the OCT4 protein was related to lymph node metastasis and TNM stage (p < 0.05), but not to gender, age and position of the tumor (p > 0.05).
OCT4 is expressed in laryngeal squamous carcinoma tissues and is closely related to the cell differentiation of laryngeal carcinoma, lymph node metastasis and clinical stage.
探讨 OCT4 在喉鳞状细胞癌组织中的表达及其临床意义。
采用免疫组织化学染色法分析 61 例喉鳞状细胞癌及 10 例癌旁正常喉组织中 OCT4 的表达。
正常喉组织中未见 OCT4 表达，而在喉癌组织中可见 OCT4 定位于细胞核。OCT4 在高、中分化及低分化喉鳞状细胞癌组织中的阳性表达率分别为 25.6%（11/43）和 66.7%（12/18），差异有统计学意义（p<0.01）。OCT4 蛋白的表达与淋巴结转移和 TNM 分期有关（p<0.05），而与性别、年龄及肿瘤部位无关（p>0.05）。
OCT4 在喉鳞状细胞癌组织中表达，与喉癌的细胞分化、淋巴结转移及临床分期密切相关。
