Wang Yatang, Yang Jianming, Xu Haiyan
Department of Otorhinolaryngology, Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Jul;27(14):779-83.
To investigate the expression of interleukin 17 in laryngeal squamous cell carcinoma tissues, and to evaluate the value of interleukin-17 in the biological behavior and prognosis of laryngeal squamous cell carcinoma.
Expressions of IL-17 were analyzed in 71 laryngeal squamous cell carcinoma samples and 21 cases of adjacent tissues of carcinoma as control by immunohistochemistry.
The expression of IL-17 in laryngeal squamous cell carcinoma tissues was obviously higher than that in adjacent tissues (P < 0.05). The expression of IL-17 was associated with tumor T staging, tumor differentiation, regional lymph node metastasis, distant metastasis and recurrence (P < 0.05). Log-rank test showed that the prognosis of patients was related to the primary tumor site, tumor stage, regional lymph node metastasis, distant metastasis and IL-17 expression (P < 0.05), While Cox multiple factors analysis showed that IL-17 was not an independent prognostic factors.
The expression of IL-17 may be the vital index in laryngeal squamous cell carcinoma, and it can provide some theoretical basis for the anti-tumor immunotherapy for laryngeal squamous cell carcinoma.
探讨白细胞介素17在喉鳞状细胞癌组织中的表达情况，并评估白细胞介素17在喉鳞状细胞癌生物学行为及预后中的价值。
采用免疫组织化学法分析71例喉鳞状细胞癌标本及21例癌旁组织标本（作为对照）中IL-17的表达情况。
喉鳞状细胞癌组织中IL-17的表达明显高于癌旁组织（P<0.05）。IL-17的表达与肿瘤T分期、肿瘤分化程度、区域淋巴结转移、远处转移及复发相关（P<0.05）。Log-rank检验显示患者预后与原发肿瘤部位、肿瘤分期、区域淋巴结转移、远处转移及IL-17表达有关（P<0.05），而Cox多因素分析显示IL-17不是独立的预后因素。
IL-17的表达可能是喉鳞状细胞癌的重要指标，可为喉鳞状细胞癌的抗肿瘤免疫治疗提供一定的理论依据。
