Poirier V J, Mayer-Stankeová S, Buchholz J, Vail D M, Kaser Hotz B
Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand.
Animal Cancer Centre, Ontario Veterinary College, University of Guelph, Guelph, Canada.
J Vet Intern Med. 2018 Jan;32(1):107-110. doi: 10.1111/jvim.14868. Epub 2017 Nov 13.
Sialocele is a collection of saliva that has leaked from a damaged salivary gland or duct and is surrounded by granulation tissue. Surgery is the recognized first-line treatment. Recurrence rate after surgery is 5-14%. Salivary gland tissue is very sensitive to radiation therapy (RT).
HYPOTHESIS/OBJECTIVES: Radiation therapy will be useful for the treatment of sialocele. The aims were to characterize response rate and clinical course of dogs with sialocele treated with RT and to determine a starting dose for clinical use.
Eleven dogs with sialocele.
Retrospective study of response and outcome after RT.
All dogs had cervical sialocele. Seven dogs (63.6%) were treated with 3 weekly fractions of 4 Gray (Gy); (total dose, 12 Gy). Three dogs (27.3%) received 4 fractions of 4 Gy (16 Gy) and 1 dog received 5 fractions of 4 Gy (20 Gy) on a Monday-Wednesday-Friday schedule. Six dogs (54%) achieved a complete response (CR), and 5 dogs (45%) achieved a partial response (PR). Three dogs had progression of their sialocele 2, 3, and 9 months after RT; all three had received 12 Gy initially and 2 received 2 additional fractions of 4 Gy (cumulative total dose, 20 Gy) and subsequently achieved remission for >2 years.
Radiation therapy is useful for the treatment of recurrent sialocele refractory to surgical management and a minimum total dose of 16 or 20 Gy in 4 Gy fractions appears effective.
涎囊肿是指从受损唾液腺或导管漏出并被肉芽组织包绕的唾液积聚。手术是公认的一线治疗方法。手术后复发率为5%-14%。唾液腺组织对放射治疗（RT）非常敏感。
假设/目的：放射治疗对涎囊肿的治疗有效。目的是描述接受RT治疗的涎囊肿犬的缓解率和临床病程，并确定临床使用的起始剂量。
11只患有涎囊肿的犬。
对RT后的反应和结果进行回顾性研究。
所有犬均患有颈部涎囊肿。7只犬（63.6%）接受了3次每周4格雷（Gy）的分次照射（总剂量12 Gy）；3只犬（27.3%）接受了4次4 Gy的照射（16 Gy），1只犬在周一至周五的日程安排下接受了5次4 Gy的照射（20 Gy）。6只犬（54%）达到完全缓解（CR），5只犬（45%）达到部分缓解（PR）。3只犬在RT后2、3和9个月涎囊肿进展；这3只犬最初均接受了12 Gy的照射，其中2只又额外接受了2次4 Gy的照射（累积总剂量20 Gy），随后缓解超过2年。
放射治疗对手术治疗难治的复发性涎囊肿有效，以4 Gy分次给予的最低总剂量16或20 Gy似乎有效。
