Bae Jeong-Yeol, Kim Jung-Il, Kim Jin-Young, Joung Guk-Il, Lee Hong-Ju, Lee Jae-Beom, Song Joong-Hyun
Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Republic of Korea.
Ulsan S Animal Medical Center, Ulsan 44726, Republic of Korea.
Animals (Basel). 2023 Dec 28;14(1):120. doi: 10.3390/ani14010120.
Dogs with sialocele often have concurrent hypercortisolism or are receiving long-term glucocorticoid treatment. However, their association has not been investigated. This retrospective matched case-control study investigated the association between hypercortisolism, long-term glucocorticoid treatment, and sialocele in dogs. We retrospectively reviewed the records from 1 January 2018 to 31 December 2022. Records of 19 dogs diagnosed with sialocele were investigated for hypercortisolism and long-term glucocorticoid treatment. Two age- and breed-matched controls for each sialocele dog (38 dogs) were investigated for the same concurrent diseases. Logistic regression analysis was used. The odds of sialocele in dogs with hypercortisolism were 15.56 times those of dogs without hypercortisolism ( = 0.02; 95% CI: 1.54-156.79). The odds of sialocele in dogs with long-term glucocorticoid treatment (median, 8 months; range, 5-13) were 7.78 times those of dogs without long-term glucocorticoid treatment ( = 0.03; 95% CI: 1.23-49.40). No associations were found between age, sex, body weight, and the presence of sialocele. The results indicate that sialocele was significantly associated with hypercortisolism and long-term glucocorticoid treatment in dogs. Therefore, dogs with hypercortisolism or receiving long-term glucocorticoid therapy should be screened for possible sialocele. Additionally, dogs with sialocele should be identified for concurrent hypercortisolism and prolonged glucocorticoid exposure.
患有唾液囊肿的犬只常常并发皮质醇增多症或正在接受长期糖皮质激素治疗。然而，它们之间的关联尚未得到研究。这项回顾性匹配病例对照研究调查了犬只皮质醇增多症、长期糖皮质激素治疗与唾液囊肿之间的关联。我们回顾性分析了2018年1月1日至2022年12月31日的记录。对19只被诊断为唾液囊肿的犬只记录进行了皮质醇增多症和长期糖皮质激素治疗情况的调查。为每只唾液囊肿犬（共19只）匹配了两只年龄和品种相符的对照犬（共38只），并对它们相同的并发疾病进行调查。采用逻辑回归分析。患有皮质醇增多症的犬只发生唾液囊肿的几率是未患皮质醇增多症犬只的15.56倍（P = 0.02；95%置信区间：1.54 - 156.79）。接受长期糖皮质激素治疗（中位数为8个月；范围为5 - 13个月）的犬只发生唾液囊肿的几率是未接受长期糖皮质激素治疗犬只的7.78倍（P = 0.03；95%置信区间：1.23 - 49.40）。未发现年龄、性别、体重与唾液囊肿的发生之间存在关联。结果表明，犬只唾液囊肿与皮质醇增多症和长期糖皮质激素治疗显著相关。因此，患有皮质醇增多症或接受长期糖皮质激素治疗的犬只应筛查是否可能患有唾液囊肿。此外，患有唾液囊肿的犬只应检查是否并发皮质醇增多症以及是否长期暴露于糖皮质激素。
