Pal Kuntal, Hoque Abdul, Volla Chandra M R
Department of Chemistry, Indian Institute of Technology-Bombay, Powai, Mumbai, 400076, India.
Chemistry. 2018 Feb 21;24(11):2558-2564. doi: 10.1002/chem.201705036. Epub 2017 Dec 5.
A convenient and simple, Rh -catalyzed denitrogenative method for the synthesis of biologically interesting 2-amino-benzoxazinones and 5-amino-oxadiazoles from readily available isatoic anhydrides and oxadiazolones has been developed. These reactions proceed via an O-H insertion onto α-imino Rh -carbenoid species followed by a rearrangement. The scope of the reaction can also be extended to benzoxazinones to access amino-substituted benzoxazines.
已开发出一种简便的铑催化脱氮方法，可从容易获得的异吲哚酮酸酐和恶二唑酮合成具有生物学意义的2-氨基苯并恶嗪酮和5-氨基恶二唑。这些反应通过O-H插入α-亚氨基铑-卡宾物种，随后进行重排来进行。该反应的范围还可扩展至苯并恶嗪酮，以制备氨基取代的苯并恶嗪。
