Wallace Mandy L, MacPhail Catriona M, Monnet Eric
From the Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, Georgia (M.L.W.); and the Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado (C.M.M., E.M.).
J Am Anim Hosp Assoc. 2018 Jan/Feb;54(1):46-49. doi: 10.5326/JAAHA-MS-6534. Epub 2017 Nov 13.
Postoperative seizures occur in 5-12% of dogs following surgical attenuation of congenital extrahepatic portosystemic shunts (CEPSS) and are often refractory to treatment. Because pugs are predisposed to necrotizing meningoencephalitis, they may be at higher risk of developing neurologic complications after CEPSS attenuation. We hypothesized that pugs have a higher prevalence of postoperative neurologic complications and that pugs who died due to neurologic complications would have evidence of encephalitis at necropsy. Records were searched for pugs that had undergone surgical correction of a single extrahepatic CEPSS. Fourteen pugs met the inclusion criteria and were compared with a control group of 30 dogs of varying breeds who also underwent surgical attenuation for a single CEPSS. Four of 14 pugs (28.6%) died or were euthanized within 1 mo after surgery for neurologic complications, compared with only 1 of 30 dogs in the control group (P < .029). No evidence of necrotizing meningoencephalitis was seen on necropsy. Pugs may be at an increased risk of developing fatal neurologic complications following surgical attenuation for CEPSS. Further studies are indicated to investigate reasons for this increased risk, as well as to determine any factors that may indicate which pugs are at higher risk.
先天性肝外门体分流（CEPSS）手术减流术后，5% - 12%的犬会发生术后癫痫发作，且这些癫痫发作往往难以治疗。由于哈巴狗易患坏死性脑膜脑炎，它们在CEPSS减流术后发生神经系统并发症的风险可能更高。我们假设哈巴狗术后神经系统并发症的发生率更高，且因神经系统并发症死亡的哈巴狗在尸检时会有脑炎的证据。检索了接受单一肝外CEPSS手术矫正的哈巴狗的记录。14只哈巴狗符合纳入标准，并与30只不同品种的犬组成的对照组进行比较，这些犬也接受了单一CEPSS的手术减流。14只哈巴狗中有4只（28.6%）在术后1个月内因神经系统并发症死亡或被安乐死，而对照组30只犬中只有1只出现这种情况（P <.029）。尸检未发现坏死性脑膜脑炎的证据。哈巴狗在接受CEPSS手术减流后发生致命神经系统并发症的风险可能会增加。需要进一步研究来调查这种风险增加的原因，以及确定可能表明哪些哈巴狗风险更高的任何因素。
