Percival S L, Mayer D, Malone M, Swanson T, Gibson D, Schultz G
CEO and Professor (honorary), Centre of Excellence in Biofilm Science and Technologies (CEBST), 5D Health Protection Group Ltd and Liverpool University, Liverpool, UK.
Head of Vascular Surgery Unit, Department of Surgery, HFR Fribourg-Cantonal Hospital, Fribourg, Switzerland.
J Wound Care. 2017 Nov 2;26(11):680-690. doi: 10.12968/jowc.2017.26.11.680.
Surfactants are widely used as detergents, emulsifiers, wetting agents, foaming agents and dispersants in the cosmetics, hygiene, food and oil industries. Their use in a clinical setting is also common, particularly within the field of wound care. Many wound cleansers contain surfactants and subsequently there is available data that shows the growing potential of these wound cleansers in the enhancement of wound closure. The presence of microorganisms in wounds has been recognised as a significant factor that delay healing. In complex or chronic wounds that are complicated by biofilms, persistent inflammation or the production of non-viable tissue and slough, the use of surfactants has been shown to aid in the removal of these barriers to wound healing. The use of concentrated surfactant(poloxamer) based wound dressings represent an important component of wound management. Consequently, this article will discuss the effect of clinically used surfactants, with specific focus on a concentrated poloxamer for use against wound biofilm.
表面活性剂在化妆品、卫生、食品和石油工业中被广泛用作洗涤剂、乳化剂、湿润剂、发泡剂和分散剂。它们在临床环境中的应用也很常见，尤其是在伤口护理领域。许多伤口清洁剂都含有表面活性剂，随后有数据表明这些伤口清洁剂在促进伤口愈合方面的潜力越来越大。伤口中微生物的存在已被认为是延迟愈合的一个重要因素。在因生物膜、持续性炎症或产生无活力组织和腐肉而复杂化的复杂或慢性伤口中，表面活性剂的使用已被证明有助于消除这些伤口愈合的障碍。基于浓缩表面活性剂（泊洛沙姆）的伤口敷料的使用是伤口管理的一个重要组成部分。因此，本文将讨论临床使用的表面活性剂的作用，特别关注用于对抗伤口生物膜的浓缩泊洛沙姆。
