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LRRK2 单倍型与帕金森病发病年龄的关联。

Association of LRRK2 Haplotype With Age at Onset in Parkinson Disease.

机构信息

National Neuroscience Institute, Singapore.

Centre for Quantitative Medicine, Duke-National University of Singapore Medical School, Singapore.

出版信息

JAMA Neurol. 2018 Jan 1;75(1):127-128. doi: 10.1001/jamaneurol.2017.3363.

DOI:10.1001/jamaneurol.2017.3363
PMID:29131875
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5833493/
Abstract

This study examines the effect of risk variants on the age at onset of Parkinson disease.

摘要

本研究考察了风险变异对帕金森病发病年龄的影响。

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本文引用的文献

1
Parkinson's disease.帕金森病。
Lancet. 2015 Aug 29;386(9996):896-912. doi: 10.1016/S0140-6736(14)61393-3. Epub 2015 Apr 19.
2
LRRK2 G2385R and R1628P mutations are associated with an increased risk of Parkinson's disease in the Malaysian population.LRRK2基因的G2385R和R1628P突变与马来西亚人群患帕金森病的风险增加相关。
Biomed Res Int. 2014;2014:867321. doi: 10.1155/2014/867321. Epub 2014 Aug 28.
3
LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesis.LRRK2,一种令人费解的蛋白质:对帕金森病发病机制的见解。
Exp Neurol. 2014 Nov;261:206-16. doi: 10.1016/j.expneurol.2014.05.025. Epub 2014 Jun 4.
4
Genetic variants in sporadic Parkinson's disease: East vs West.散发性帕金森病中的遗传变异:东西方的比较。
Parkinsonism Relat Disord. 2012 Jan;18 Suppl 1:S63-5. doi: 10.1016/S1353-8020(11)70021-9.
5
LRRK2 G2385R modulates age at onset in Parkinson's disease: A multi-center pooled analysis.LRRK2基因G2385R突变对帕金森病发病年龄的影响:一项多中心汇总分析。
Am J Med Genet B Neuropsychiatr Genet. 2009 Oct 5;150B(7):1022-3. doi: 10.1002/ajmg.b.30923.
6
The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.路易小体与特发性帕金森病发病机制的相关性。
J Neurol Neurosurg Psychiatry. 1988 Jun;51(6):745-52. doi: 10.1136/jnnp.51.6.745.