Bruton Thomas A, Blum Arlene
Green Science Policy Institute, Berkeley, CA, USA.
Department of Chemistry, University of California at Berkeley, Berkeley, CA, USA.
Environ Health. 2017 Nov 14;16(1):120. doi: 10.1186/s12940-017-0321-6.
The drinking water of more than six million Americans in numerous communities has been found to contain highly fluorinated chemicals at concentrations of concern. Certain of these chemicals, including perfluorooctanoic acid and perfluorooctane sulfonic acid, are known to be persistent, bioaccumulative, and associated with adverse health outcomes in humans and animal models. The possible health impacts of exposure to highly fluorinated chemicals are of great concern to communities whose water has been impacted. Community members want information, and are asking for biomonitoring, exposure pathway analysis, and health studies. Governmental agencies are striving to deal with these multiple concerns in the face of information and resource constraints. We propose the development of a high-level research strategy to maximize what can be learned about health effects of highly fluorinated chemicals and methods to reduce or eliminate exposure. We suggest coordinating the research across multiple communities for greater statistical power. If implemented, such a strategy could help to generate information and evidence integration to enable regulatory decision making and contribute to reducing future exposures.
在众多社区中，已发现超过600万美国人的饮用水含有令人担忧浓度的高氟化学物质。其中某些化学物质，包括全氟辛酸和全氟辛烷磺酸，已知具有持久性、生物累积性，并与人类和动物模型中的不良健康后果相关。饮用水受到影响的社区对接触高氟化学物质可能产生的健康影响极为关注。社区成员想要了解相关信息，并要求进行生物监测、接触途径分析和健康研究。面对信息和资源限制，政府机构正在努力应对这些多重问题。我们提议制定一项高级研究战略，以最大限度地了解高氟化学物质的健康影响以及减少或消除接触的方法。我们建议跨多个社区协调研究，以提高统计效力。如果实施这样的战略，有助于生成信息和证据整合，以支持监管决策，并有助于减少未来的接触。
