Frisbee Stephanie J, Brooks A Paul, Maher Arthur, Flensborg Patsy, Arnold Susan, Fletcher Tony, Steenland Kyle, Shankar Anoop, Knox Sarah S, Pollard Cecil, Halverson Joel A, Vieira Verónica M, Jin Chuanfang, Leyden Kevin M, Ducatman Alan M
Department of Community Medicine, West Virginia University School of Medicine, Morgantown, West Virginia 26506-9105, USA.
Environ Health Perspect. 2009 Dec;117(12):1873-82. doi: 10.1289/ehp.0800379. Epub 2009 Jul 13.
The C8 Health Project was created, authorized, and funded as part of the settlement agreement reached in the case of Jack W. Leach, et al. v. E.I. du Pont de Nemours & Company (no. 01-C-608 W.Va., Wood County Circuit Court, filed 10 April 2002). The settlement stemmed from the perfluorooctanoic acid (PFOA, or C8) contamination of drinking water in six water districts in two states near the DuPont Washington Works facility near Parkersburg, West Virginia.
This study reports on the methods and results from the C8 Health Project, a population study created to gather data that would allow class members to know their own PFOA levels and permit subsequent epidemiologic investigations.
Final study participation was 69,030, enrolled over a 13-month period in 2005-2006. Extensive data were collected, including demographic data, medical diagnoses (both self-report and medical records review), clinical laboratory testing, and determination of serum concentrations of 10 perfluorocarbons (PFCs). Here we describe the processes used to collect, validate, and store these health data. We also describe survey participants and their serum PFC levels.
The population geometric mean for serum PFOA was 32.91 ng/mL, 500% higher than previously reported for a representative American population. Serum concentrations for perfluorohexane sulfonate and perfluorononanoic acid were elevated 39% and 73% respectively, whereas perfluorooctanesulfonate was present at levels similar to those in the U.S. population.
This largest known population study of community PFC exposure permits new evaluations of associations between PFOA, in particular, and a range of health parameters. These will contribute to understanding of the biology of PFC exposure. The C8 Health Project also represents an unprecedented effort to gather basic data on an exposed population; its achievements and limitations can inform future legal settlements for populations exposed to environmental contaminants.
C8健康项目是根据杰克·W·利奇等人诉伊士曼·杜邦公司（第01 - C - 608号，西弗吉尼亚州伍德县巡回法院，2002年4月10日立案）一案达成的和解协议设立、授权并资助的。该和解源于西弗吉尼亚州帕克斯堡附近杜邦华盛顿工厂附近两个州六个水区饮用水中的全氟辛酸（PFOA，即C8）污染。
本研究报告了C8健康项目的方法和结果，该项目是一项人群研究，旨在收集数据，使集体诉讼成员了解自己的全氟辛酸水平，并为后续的流行病学调查提供依据。
最终有69,030人参与了研究，于2005年至2006年的13个月期间招募。收集了大量数据，包括人口统计学数据、医学诊断（自我报告和病历审查）、临床实验室检测以及10种全氟碳化合物（PFCs）血清浓度的测定。在此，我们描述了收集、验证和存储这些健康数据所使用的过程。我们还描述了调查参与者及其血清全氟碳化合物水平。
血清全氟辛酸的人群几何平均值为32.91 ng/mL，比之前报道的美国代表性人群高出500%。全氟己烷磺酸和全氟壬酸的血清浓度分别升高了39%和73%，而全氟辛烷磺酸的水平与美国人群相似。
这项已知最大规模的社区全氟碳化合物暴露人群研究，使得对全氟辛酸与一系列健康参数之间的关联进行新的评估成为可能。这些评估将有助于理解全氟碳化合物暴露的生物学机制。C8健康项目也是为收集暴露人群基础数据所做的前所未有的努力；其成果和局限性可为未来针对暴露于环境污染物人群的法律和解提供参考。
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