Plichta Jennifer K, Campbell Brittany M, Mittendorf Elizabeth A, Hwang E Shelley
Department of Surgery, Duke University Medical Center, DUMC 3513, Durham, NC 27710, USA.
Department of Breast Surgical Oncology, University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Surg Oncol Clin N Am. 2018 Jan;27(1):51-67. doi: 10.1016/j.soc.2017.07.010.
Breast cancer staging concisely summarizes disease status, creating a framework for assessing and relaying prognostic information. The fundamental concepts and components of breast cancer staging are reviewed. The AJCC Cancer Staging Manual, which includes traditional anatomic factors, now includes additional tumor characteristics: tumor grade, estrogen receptor status, progesterone receptor status, human epidermal growth factor receptor 2 status, and (when available) multigene panel testing from the primary tumor. With these updates, staging provides the most reliable system for accurately predicting patient outcome. When the AJCC 8th edition guidelines are adopted, they will more closely reflect tumor biology.
乳腺癌分期简明扼要地总结了疾病状态，为评估和传递预后信息创建了一个框架。本文回顾了乳腺癌分期的基本概念和组成部分。美国癌症联合委员会（AJCC）癌症分期手册，其中包括传统的解剖学因素，现在还纳入了其他肿瘤特征：肿瘤分级、雌激素受体状态、孕激素受体状态、人表皮生长因子受体2状态，以及（如有可用数据）来自原发肿瘤的多基因检测。通过这些更新，分期提供了最可靠的系统来准确预测患者的预后。当采用AJCC第8版指南时，它们将更紧密地反映肿瘤生物学特性。
