Breast Surgical Oncology, Dana-Farber/Brigham and Women's Cancer Center, 450 Brookline Avenue, Suite 1470, Boston, MA 02215, USA.
Breast Surgical Oncology, Dana-Farber/Brigham and Women's Cancer Center, 450 Brookline Avenue, Suite 1220, Boston, MA 02215, USA.
Surg Clin North Am. 2018 Aug;98(4):687-702. doi: 10.1016/j.suc.2018.03.005. Epub 2018 May 21.
The American Joint Committee on Cancer staging system has evolved in response to improved imaging, refined surgical techniques, enhanced pathologic evaluation, and greater understanding of tumor biology. The 8th edition has introduced clinical and pathologic prognostic stages for breast cancer that incorporate biologic variables (grade, estrogen/progesterone receptor status, HER2 status, multigene panels) with TNM categories that define the anatomic stage. The prognostic staging system facilitates more refined stratification than the anatomic stage with respect to survival and is an important advance that maintains the clinical relevance of the staging system by taking into account tumor biology and current treatment algorithms.
美国癌症联合委员会（AJCC）分期系统是为了应对影像学的进步、手术技术的精细化、病理评估的完善以及对肿瘤生物学的深入理解而不断发展的。第 8 版引入了乳腺癌的临床和病理预后分期，其中包括生物学变量（分级、雌激素/孕激素受体状态、HER2 状态、多基因检测）与定义解剖分期的 TNM 分类的结合。与解剖分期相比，预后分期系统在生存率方面进行了更精细的分层，这是一个重要的进展，通过考虑肿瘤生物学和当前的治疗方案，保持了分期系统的临床相关性。
