Micalis Institute, Institut National de la Recherche Agronomique (INRA), AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.
Department of Bioengineering, Imperial College London, London SW7 2AZ, UK.
Trends Biotechnol. 2018 Mar;36(3):304-317. doi: 10.1016/j.tibtech.2017.10.013. Epub 2017 Nov 10.
Moving our society towards a bioeconomy requires efficient and sustainable microbial production of chemicals and fuels. Rhodotorula (Rhodosporidium) toruloides is a yeast that naturally synthesizes substantial amounts of specialty chemicals and has been recently engineered to (i) enhance its natural production of lipids and carotenoids, and (ii) produce novel industrially relevant compounds. The use of R. toruloides by companies and research groups has exponentially increased in recent years as a result of recent improvements in genetic engineering techniques and the availability of multiomics information on its genome and metabolism. This review focuses on recent engineering approaches in R. toruloides for bioproduction and explores its potential as a biotechnological chassis.
推动我们的社会向生物经济发展需要高效和可持续的微生物来生产化学品和燃料。粘红酵母（粘红酵母属）是一种天然合成大量特种化学品的酵母，最近已被工程改造为（i）增强其天然脂质和类胡萝卜素的生产，以及（ii）生产新型工业相关化合物。近年来，由于遗传工程技术的最新改进以及其基因组和代谢的多组学信息的可用性，R. toruloides 受到了公司和研究小组的大量使用，其使用呈指数级增长。本综述重点介绍了 R. toruloides 在生物生产中的最新工程方法，并探讨了其作为生物技术底盘的潜力。
