Gao Qidou, Dong Yaqi, Huang Ying, Liu Yijuan, Yang Xiaobing
College of Enology, Northwest A & F University, Yangling 712100, Shaanxi, China.
Sheng Wu Gong Cheng Xue Bao. 2023 Jun 25;39(6):2313-2333. doi: 10.13345/j.cjb.221011.
is a non-conventional red yeast that can synthesize various carotenoids and lipids. It can utilize a variety of cost-effective raw materials, tolerate and assimilate toxic inhibitors in lignocellulosic hydrolysate. At present, it is widely investigated for the production of microbial lipids, terpenes, high-value enzymes, sugar alcohols and polyketides. Given its broad industrial application prospects, researchers have carried out multi-dimensional theoretical and technological exploration, including research on genomics, transcriptomics, proteomics and genetic operation platform. Here we review the recent progress in metabolic engineering and natural product synthesis of . , and prospect the challenges and possible solutions in the construction of . cell factory.
是一种非常规红酵母，能够合成多种类胡萝卜素和脂质。它可以利用多种具有成本效益的原料，耐受并同化木质纤维素水解物中的有毒抑制剂。目前，它在微生物脂质、萜类化合物、高价值酶、糖醇和聚酮化合物的生产方面受到广泛研究。鉴于其广阔的工业应用前景，研究人员开展了多维度的理论和技术探索，包括基因组学、转录组学、蛋白质组学和遗传操作平台的研究。在此，我们综述了……在代谢工程和天然产物合成方面的最新进展，并展望了……细胞工厂构建中的挑战及可能的解决方案。
