Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan.
Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, P.O. Box 19395-5487, Tehran, Iran.
Eur J Med Chem. 2018 Jun 10;153:29-33. doi: 10.1016/j.ejmech.2017.10.065. Epub 2017 Nov 11.
Alkaloids are well-studied secondary metabolites, with recent preclinical studies evidencing that many of them exhibit anti-cancer, anti-depressant, anti-nociceptive, anti-inflammatory, anti-pyretic, anti-platelet, anti-oxidant, and anti-bacterial properties. Aconitum is a genus rich of diverse alkaloids. More than 450 alkaloids have been identified in a variety of species. Songorine is a C diterpenoid alkaloid and 12-keto analog of napelline, isolated from Aconitum soongaricum and was associated with a heterogeneous panel of biological functions. However, the bioactivity profile of this natural product has not been reviewed up to now. The present manuscript aims to summarize the most important biological activities associated with songorine administration in preclinical models. The most significant data found in the scientific literature were evaluated in order to summarize the potential clinical utility of songorine in a diverse spectrum of pathologies and conditions. Songorine and its derivatives have many pharmacological effects including anti-arrhythmic, anti-cardiac-fibrillation, excitation of synaptic transmission, anxiolytic effects, anti-nociceptive, anti-inflammatory, anti-arthritis effects, and a regenerative effect in a skin excision wound animal model. Despite its outstanding pharmacotherapeutic potential, songorine has never been tested in clinical trials. Therefore, further evaluation is required to better evaluate its clinical utility.
生物碱是研究得很好的次生代谢产物，最近的临床前研究表明，它们中的许多具有抗癌、抗抑郁、抗伤害感受、抗炎、解热、抗血小板、抗氧化和抗菌特性。乌头属是一个富含多种生物碱的属。在多种物种中已经鉴定出超过 450 种生物碱。山莨菪堿是一种 C 二萜生物碱，是那可汀的 12-酮类似物，从乌头属中分离出来，与一系列不同的生物学功能有关。然而，到目前为止，还没有对这种天然产物的生物活性进行综述。本文旨在总结与山莨菪堿在临床前模型中给药相关的最重要的生物学活性。评估了科学文献中最显著的数据，以总结山莨菪堿在多种病理和病症中的潜在临床应用。山莨菪堿及其衍生物具有许多药理作用，包括抗心律失常、抗心脏纤颤、兴奋突触传递、抗焦虑作用、镇痛作用、抗炎作用、抗关节炎作用和皮肤切除伤口动物模型中的再生作用。尽管具有突出的治疗潜力，但山莨菪堿从未在临床试验中进行过测试。因此，需要进一步评估以更好地评估其临床应用。
