Visanji Naomi P, Lang Anthony E, Munoz David G
Morton and Gloria Shulman Movement Disorders Centre and Edmund J. Safra Program in Parkinson's disease, Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario, Canada.
Morton and Gloria Shulman Movement Disorders Centre and Edmund J. Safra Program in Parkinson's disease, Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario, Canada.
Neurosci Lett. 2018 Feb 5;665:18-21. doi: 10.1016/j.neulet.2017.11.001. Epub 2017 Nov 11.
Recent reports have characterized functional lymphatic vessels, which drain both fluid and immune cells from the CSF to the deep cervical lymph nodes, lining the dural sinuses in mice. If conserved in the human brain these vessels could have profound implications for neuroinflammatory and neurodegenerative diseases. We provide evidence of the presence of lymphatic vessels in human dura obtained at autopsy, at the level of the superior sagittal sinus, in 4 individuals. Immunohistochemistry for the lymphatic vessel endothelial cell marker podoplanin revealed the widespread presence of multiple structures with a distinct lumen distributed throughout the superior sagittal sinus. These vessels provide a putative infrastructure for drainage of macromolecules from the brain parenchyma and represent an exciting avenue of exploration for involvement in the pathogenesis of neurodegenerative proteinopathies including Parkinson's disease.
最近的报告描述了功能性淋巴管，其将脑脊液中的液体和免疫细胞引流至小鼠硬脑膜窦内衬的颈深淋巴结。如果在人类大脑中也存在这种淋巴管，那么它们可能对神经炎症性疾病和神经退行性疾病产生深远影响。我们提供了证据，证明在4名个体尸检获取的上矢状窦水平的人类硬脑膜中存在淋巴管。针对淋巴管内皮细胞标志物血小板内皮细胞黏附分子-1的免疫组织化学显示，在上矢状窦中广泛存在多个具有明显管腔的结构。这些血管为从脑实质中引流大分子提供了一种假定的结构基础，并且代表了一条令人兴奋的探索途径，可用于研究包括帕金森病在内的神经退行性蛋白病的发病机制。
