Department of Occupational Medicine, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.
Department of Occupational Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan.
BMJ Open. 2017 Nov 12;7(11):e017117. doi: 10.1136/bmjopen-2017-017117.
The global prevalence of hepatitis C virus (HCV) is approximately 2%-3%, and the prevalence of the positive anti-HCV antibody has been increasing. Several studies have evaluated regional adipose tissue distribution and metabolism over the past decades. However, no study has focused on the gender difference in visceral obesity among patients with HCV infection.
Retrospective cross-sectional study.
We reviewed the medical records of patients who visited a hospital in Southern Taiwan for health check-up from 2013 to 2015.
A total of 1267 medical records were collected. We compared patient characteristics, variables related to metabolic risk and body composition measured using bioelectrical impedance analysis between the groups. Regression models were built to adjust for possible confounding factors.
The prevalence rate of the positive anti-HCV antibody was 8.8% in the study population, 8.5% in men and 9.2% in women. Men with HCV infection tended to be older and have lower total cholesterol levels and higher alanine aminotransferase (ALT) levels (p<0.001). Women with HCV infection tended to be older and have higher levels of fasting glucose and ALT (p<0.001). After adjusting for confounding factors, body fat percentage, fat-free mass/body weight (BW) and muscle mass/BW were found to be the independent determinants of visceral obesity in patients without HCV infection (p<0.001). However, the trend was not such obvious in patients with HCV infection, though still statistically significant (p<0.05). Furthermore, the trend was less significant in men with HCV infection.
The findings suggested that HCV modulates host lipid metabolism and distribution to some extent, and a gender difference was also noted.
全球丙型肝炎病毒（HCV）的流行率约为 2%-3%，抗-HCV 抗体的阳性率一直在上升。过去几十年，已有多项研究评估了区域性脂肪组织分布和代谢。然而，尚无研究关注 HCV 感染患者内脏肥胖的性别差异。
回顾性横断面研究。
我们回顾了 2013 年至 2015 年期间在台湾南部一家医院进行健康检查的患者的病历。
共收集了 1267 份病历。我们比较了两组患者的特征、与代谢风险相关的变量以及使用生物电阻抗分析测量的身体成分。建立回归模型以调整可能的混杂因素。
研究人群中抗-HCV 抗体的阳性率为 8.8%，男性为 8.5%，女性为 9.2%。感染 HCV 的男性年龄较大，总胆固醇水平较低，丙氨酸氨基转移酶（ALT）水平较高（p<0.001）。感染 HCV 的女性年龄较大，空腹血糖和 ALT 水平较高（p<0.001）。调整混杂因素后，无 HCV 感染患者的体脂肪百分比、去脂体重/体重（BW）和肌肉量/BW 是内脏肥胖的独立决定因素（p<0.001）。然而，这种趋势在 HCV 感染患者中并不明显，尽管仍具有统计学意义（p<0.05）。此外，这种趋势在 HCV 感染男性中不太明显。
研究结果表明，HCV 在某种程度上调节宿主的脂质代谢和分布，并且注意到了性别差异。
