Clinical Research Fellow in Rheumatology, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK.
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Clin Rheumatol. 2018 Feb;37(2):297-305. doi: 10.1007/s10067-017-3908-y. Epub 2017 Nov 13.
Psoriatic arthritis is a chronic inflammatory arthritis that is part of the spondyloarthropathy group of rheumatic diseases and has associated co-morbidities. It can present with various clinical manifestations making diagnosis and treatment challenging, resulting in significant disability and reduced quality of life for patients. Whilst there have been advances in understanding the pathogenic mechanisms of the disease which have resulted in targeted therapies, there is still the need for further studies as some patients fail or are intolerant of current therapies. Better identification of early disease and knowledge of prognostic markers would enable clinicians to initiate appropriate therapy with the expectation that early aggressive treatment will minimise joint damage progression. Improved knowledge of the condition would also enable clinicians to better tailor specific treatment strategies for each of the various clinical domains in psoriatic arthritis.
银屑病关节炎是一种慢性炎症性关节炎，属于脊柱关节病类风湿疾病的一种，且伴有相关合并症。它可以表现出各种不同的临床表现，这使得诊断和治疗具有挑战性，导致患者出现显著的残疾和生活质量下降。尽管人们对疾病的发病机制有了更深入的了解，并由此产生了靶向治疗方法，但仍需要进一步的研究，因为有些患者对现有疗法没有反应或不耐受。更好地识别早期疾病并了解预后标志物，将使临床医生能够用预期的早期积极治疗来最小化关节损伤进展的方式，启动适当的治疗。对病情的更好了解，也将使临床医生能够为银屑病关节炎的各个不同临床领域制定更具体的治疗策略。
