FitzGerald O, Kane D
Department of Rheumatology, St. Vincent's Hospital, Dublin, Ireland.
Curr Opin Rheumatol. 1997 Jul;9(4):295-301. doi: 10.1097/00002281-199707000-00004.
Psoriatic arthritis is a common chronic rheumatic disease that may result in considerable joint damage if left untreated. Recent clinical studies have focused on the identification of poor prognostic factors. Early, aggressive treatment is indicated in patients with significant joint inflammation and certain HLA antigens. Immunopathogenic evidence continues to point toward an HLA class I-mediated disease with perhaps an important role for CD8+ T cells. Although few basic research publications discuss psoriatic arthritis, studies in the areas of spondyloarthropathy and psoriasis continue to shed light on disease mechanisms. Greater collaboration is advocated among researchers in these areas and those interested in achieving a better understanding of the disease pathogenesis of psoriatic arthritis.
银屑病关节炎是一种常见的慢性风湿性疾病，如果不进行治疗，可能会导致严重的关节损伤。最近的临床研究集中在识别不良预后因素。对于有明显关节炎症和某些 HLA 抗原的患者，建议尽早进行积极治疗。免疫病理学证据继续指向一种由 HLA I 类介导的疾病，CD8+ T 细胞可能起重要作用。尽管很少有基础研究出版物讨论银屑病关节炎，但脊柱关节病和银屑病领域的研究继续为疾病机制提供线索。提倡这些领域的研究人员与那些有兴趣更好地理解银屑病关节炎发病机制的人员之间加强合作。
