城市和高度工业化地区空气中颗粒物在人类淋巴细胞培养物中诱导的姐妹染色单体交换和染色体畸变的比较研究。

Comparative study of sister-chromatid exchanges and chromosomal aberrations induced by airborne particulates from an urban and a highly industrialized location in human lymphocyte cultures.

作者信息

Hadnagy W, Seemayer N H, Tomingas R, Ivanfy K

机构信息

Medical Institute of Environmental Hygiene, University of Düsseldorf, F.R.G.

出版信息

Mutat Res. 1989 Jan-Feb;225(1-2):27-32. doi: 10.1016/0165-7992(89)90028-6.

DOI:10.1016/0165-7992(89)90028-6

PMID:2913489

Abstract

Cytogenetic effects induced by extracts of airborne particulates in human lymphocyte cultures were studied with regard to local and seasonal variations. Samples of airborne particulates were collected from an urban and a highly industrialized area in March and October, respectively. All extracts of particulates induced a significant increase of sister-chromatid exchanges (SCE) in a dose-dependent manner. Referring to the induction of sister-chromatid exchanges, local and seasonal differences were observed. Samples from the industrialized area revealed the highest activities. In addition, SCE rates found for March samples were always higher than those for October for both locations. Furthermore, a remarkable, significant induction of chromosomal aberrations occurred with all samples from both locations and sampling periods. Aspects of health risk evaluation for exposed human populations are discussed with respect to the observed cytogenetic effects of airborne particulates in human lymphocyte cultures.

摘要

研究了空气传播颗粒物提取物在人类淋巴细胞培养物中诱导的细胞遗传学效应，涉及局部和季节变化。分别于3月和10月从一个城市地区和一个高度工业化地区采集空气传播颗粒物样本。所有颗粒物提取物均以剂量依赖方式诱导姐妹染色单体交换（SCE）显著增加。关于姐妹染色单体交换的诱导，观察到了局部和季节差异。来自工业化地区的样本显示出最高活性。此外，两个地点3月样本的SCE率始终高于10月样本。此外，两个地点和采样时期的所有样本均出现了明显且显著的染色体畸变诱导。针对人类淋巴细胞培养物中空气传播颗粒物所观察到的细胞遗传学效应，讨论了暴露人群健康风险评估的相关方面。