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Chemical Burns of the Eye: The Role of Retinal Injury and New Therapeutic Possibilities.眼部化学灼伤：视网膜损伤的作用及新的治疗可能性
Cornea. 2018 Feb;37(2):248-251. doi: 10.1097/ICO.0000000000001438.
2
Mechanisms of Retinal Damage after Ocular Alkali Burns.眼部碱烧伤后视网膜损伤的机制
Am J Pathol. 2017 Jun;187(6):1327-1342. doi: 10.1016/j.ajpath.2017.02.005. Epub 2017 Apr 13.
3
Sustained Subconjunctival Delivery of Infliximab Protects the Cornea and Retina Following Alkali Burn to the Eye.英夫利昔单抗结膜下持续给药可保护眼碱烧伤后的角膜和视网膜。
Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):96-105. doi: 10.1167/iovs.16-20339.
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Alkali burn to the eye: protection using TNF-α inhibition.眼部碱烧伤：使用 TNF-α 抑制进行保护。
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Glaucoma After Corneal Trauma or Surgery-A Rapid, Inflammatory, IOP-Independent Pathway.角膜创伤或手术后的青光眼——一种快速、炎症性、与眼压无关的途径。
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The prophylactic value of TNF-α inhibitors against retinal cell apoptosis and optic nerve axon loss after corneal surgery or trauma.TNF-α 抑制剂对角膜手术后或创伤后视网膜细胞凋亡和视神经轴突丢失的预防作用。
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Boston Keratoprosthesis Outcomes in Severe Ocular Chemical Burns in Southern China: A Retrospective Study.中国南方严重眼部化学烧伤患者使用波士顿人工角膜的疗效：一项回顾性研究
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The Role of Microglia and Peripheral Monocytes in Retinal Damage after Corneal Chemical Injury.小胶质细胞和外周单核细胞在角膜化学伤后视网膜损伤中的作用。
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TNF-α Suppression Attenuates Limbal Stem Cell Damage in Ocular Injury.肿瘤坏死因子-α抑制可减轻眼外伤中角膜缘干细胞损伤。
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Th17 Activation and Th17/Treg Imbalance in Prolonged Anterior Intraocular Inflammation after Ocular Alkali Burn.眼碱烧伤后延长性眼前段炎症中 Th17 的激活和 Th17/Treg 失衡。
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Inflamm Res. 2022 Jun;71(5-6):577-590. doi: 10.1007/s00011-022-01565-3. Epub 2022 Apr 12.
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The Epidemiology of Chemical Burns Among the Patients Referred to Burn Centers in Shiraz, Southern Iran, 2008-2018.2008 - 2018年伊朗南部设拉子烧伤中心收治患者中化学烧伤的流行病学情况
Bull Emerg Trauma. 2021 Oct;9(4):195-200. doi: 10.30476/BEAT.2021.90754.1261.
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Intrinsic Optical Properties of Boston Keratoprosthesis.Boston 角膜假体的固有光学特性。
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本文引用的文献

1
Boston Keratoprosthesis in Stevens-Johnson syndrome: a case of using infliximab to prevent tissue necrosis.史蒂文斯-约翰逊综合征中的波士顿人工角膜：一例使用英夫利昔单抗预防组织坏死的病例
Digit J Ophthalmol. 2009 Feb 20;15(1):5-8. doi: 10.5693/djo.01.2009.002. eCollection 2009.
2
Mechanisms of Retinal Damage after Ocular Alkali Burns.眼部碱烧伤后视网膜损伤的机制
Am J Pathol. 2017 Jun;187(6):1327-1342. doi: 10.1016/j.ajpath.2017.02.005. Epub 2017 Apr 13.
3
Sustained Subconjunctival Delivery of Infliximab Protects the Cornea and Retina Following Alkali Burn to the Eye.英夫利昔单抗结膜下持续给药可保护眼碱烧伤后的角膜和视网膜。
Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):96-105. doi: 10.1167/iovs.16-20339.
4
Effect of Penetrating Keratoplasty and Keratoprosthesis Implantation on the Posterior Segment of the Eye.穿透性角膜移植术和角膜假体植入术对眼后段的影响。
Invest Ophthalmol Vis Sci. 2016 Apr;57(4):1643-8. doi: 10.1167/iovs.15-17557.
5
Infliximab after Boston Keratoprosthesis in Stevens-Johnson Syndrome: An Update.英夫利昔单抗用于史蒂文斯-约翰逊综合征患者接受波士顿人工角膜移植术后：最新进展
Ocul Immunol Inflamm. 2017 Jun;25(3):413-417. doi: 10.3109/09273948.2016.1145237. Epub 2016 Mar 25.
6
A Drug Delivery System for Administration of Anti-TNF-α Antibody.一种用于注射抗TNF-α抗体的药物递送系统。
Transl Vis Sci Technol. 2016 Mar 11;5(2):11. doi: 10.1167/tvst.5.2.11. eCollection 2016 Mar.
7
Incidence of Stevens-Johnson Syndrome and Chemical Burns to the Eye.史蒂文斯-约翰逊综合征及眼部化学灼伤的发病率。
Cornea. 2015 Dec;34(12):1527-33. doi: 10.1097/ICO.0000000000000646.
8
Technique of combined glaucoma tube shunt and keratoprosthesis implantation.青光眼引流管联合角膜移植术技术
J Glaucoma. 2014 Oct-Nov;23(8):501-7. doi: 10.1097/IJG.0b013e31829d9c00.
9
Glaucoma progression and role of glaucoma surgery in patients with Boston keratoprosthesis.青光眼进展及青光眼手术在波士顿角膜镜患者中的作用。
Cornea. 2014 Apr;33(4):349-54. doi: 10.1097/ICO.0000000000000067.
10
Alkali burn to the eye: protection using TNF-α inhibition.眼部碱烧伤：使用 TNF-α 抑制进行保护。
Cornea. 2014 Apr;33(4):382-9. doi: 10.1097/ICO.0000000000000071.

眼部化学灼伤：视网膜损伤的作用及新的治疗可能性

Chemical Burns of the Eye: The Role of Retinal Injury and New Therapeutic Possibilities.

作者信息

Dohlman Claes H, Cade Fabiano, Regatieri Caio V, Zhou Chengxin, Lei Fengyang, Crnej Alja, Harissi-Dagher Mona, Robert Marie-Claude, Papaliodis George N, Chen Dongfeng, Aquavella James V, Akpek Esen K, Aldave Anthony J, Sippel Kimberly C, DʼAmico Donald J, Dohlman Jan G, Fagerholm Per, Wang Liqiang, Shen Lucy Q, González-Andrades Miguel, Chodosh James, Kenyon Kenneth R, Foster C Stephen, Pineda Roberto, Melki Samir, Colby Kathryn A, Ciolino Joseph B, Vavvas Demetrios G, Kinoshita Shigeru, Dana Reza, Paschalis Eleftherios I

机构信息

Cornea Service and Boston Keratoprosthesis Laboratory, Massachusetts Eye and Ear Infirmary and Schepens Eye Research Institute, Harvard Medical School, Boston, MA.

出版信息

Cornea. 2018 Feb;37(2):248-251. doi: 10.1097/ICO.0000000000001438.

DOI:10.1097/ICO.0000000000001438
PMID:29135604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8728745/
Abstract

PURPOSE

To propose a new treatment paradigm for chemical burns to the eye - in the acute and chronic phases.

METHODS

Recent laboratory and clinical data on the biology and treatment of chemical burns are analyzed.

RESULTS

Corneal blindness from chemical burns can now be successfully treated with a keratoprosthesis, on immediate and intermediate bases. Long term outcomes, however, are hampered by early retinal damage causing glaucoma. New data suggest that rapid diffusion of inflammatory cytokines posteriorly (TNF-α, etc) can severely damage the ganglion cells. Prompt anti-TNF-α treatment is markedly neuroprotective. Long term profound reduction of the intraocular pressure is also vital.

CONCLUSION

A new regimen, in addition to standard treatment, for severe chemical burns is proposed. This involves tumor necrosis factor alpha (TNF-α) inhibition promptly after the accident (primarily for retinal neuroprotection), prophylactic maximal lowering of the intraocular pressure (starting immediately), and keratoprosthesis implantation in a later quiet state.

摘要

目的

提出一种针对眼部化学烧伤急性期和慢性期的新治疗模式。

方法

分析近期有关化学烧伤生物学及治疗的实验室和临床数据。

结果

现在可以通过角膜移植术即时和中期成功治疗化学烧伤导致的角膜盲。然而，长期预后受到早期视网膜损伤导致青光眼的阻碍。新数据表明，炎症细胞因子（如肿瘤坏死因子-α等）向后快速扩散会严重损害神经节细胞。及时的抗肿瘤坏死因子-α治疗具有显著的神经保护作用。长期深度降低眼压也至关重要。

结论

除标准治疗外，还提出了一种针对严重化学烧伤的新方案。这包括事故后立即抑制肿瘤坏死因子-α（主要用于视网膜神经保护）、预防性最大程度降低眼压（立即开始）以及在后期病情稳定时进行角膜移植术。