Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg 69117, Germany.
Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest H-1117, Hungary.
Nucleic Acids Res. 2018 Jan 4;46(D1):D428-D434. doi: 10.1093/nar/gkx1077.
Short linear motifs (SLiMs) are protein binding modules that play major roles in almost all cellular processes. SLiMs are short, often highly degenerate, difficult to characterize and hard to detect. The eukaryotic linear motif (ELM) resource (elm.eu.org) is dedicated to SLiMs, consisting of a manually curated database of over 275 motif classes and over 3000 motif instances, and a pipeline to discover candidate SLiMs in protein sequences. For 15 years, ELM has been one of the major resources for motif research. In this database update, we present the latest additions to the database including 32 new motif classes, and new features including Uniprot and Reactome integration. Finally, to help provide cellular context, we present some biological insights about SLiMs in the cell cycle, as targets for bacterial pathogenicity and their functionality in the human kinome.
短线性基序 (SLiMs) 是蛋白质结合模块，在几乎所有细胞过程中都发挥着重要作用。SLiMs 短而灵活，通常高度退化，难以描述和检测。真核线性基序 (ELM) 资源 (elm.eu.org) 专注于 SLiMs，包含一个经过人工整理的数据库，其中包含超过 275 个基序类别和超过 3000 个基序实例，以及一个在蛋白质序列中发现候选 SLiMs 的管道。15 年来，ELM 一直是基序研究的主要资源之一。在本次数据库更新中，我们介绍了数据库的最新添加内容，包括 32 个新的基序类别，以及新的功能，包括与 Uniprot 和 Reactome 的整合。最后，为了帮助提供细胞环境，我们介绍了细胞周期中 SLiMs 的一些生物学见解，以及它们作为细菌致病性靶标的功能及其在人类激酶组中的功能。
