Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg 69117, Germany.
Collaboration for joint PhD degree between EMBL and Heidelberg University, Faculty of Biosciences, Germany.
Nucleic Acids Res. 2024 Jan 5;52(D1):D442-D455. doi: 10.1093/nar/gkad1058.
Short Linear Motifs (SLiMs) are the smallest structural and functional components of modular eukaryotic proteins. They are also the most abundant, especially when considering post-translational modifications. As well as being found throughout the cell as part of regulatory processes, SLiMs are extensively mimicked by intracellular pathogens. At the heart of the Eukaryotic Linear Motif (ELM) Resource is a representative (not comprehensive) database. The ELM entries are created by a growing community of skilled annotators and provide an introduction to linear motif functionality for biomedical researchers. The 2024 ELM update includes 346 novel motif instances in areas ranging from innate immunity to both protein and RNA degradation systems. In total, 39 classes of newly annotated motifs have been added, and another 17 existing entries have been updated in the database. The 2024 ELM release now includes 356 motif classes incorporating 4283 individual motif instances manually curated from 4274 scientific publications and including >700 links to experimentally determined 3D structures. In a recent development, the InterPro protein module resource now also includes ELM data. ELM is available at: http://elm.eu.org.
短线性基序 (SLiMs) 是模块化真核蛋白的最小结构和功能组件。它们也是最丰富的，尤其是考虑到翻译后修饰时。除了作为调节过程的一部分存在于整个细胞中外，SLiMs 还被细胞内病原体广泛模拟。真核线性基序 (ELM) 资源的核心是一个具有代表性（非全面）的数据库。ELM 条目由不断增长的熟练注释者社区创建，为生物医学研究人员提供了线性基序功能的介绍。2024 年的 ELM 更新包括从先天免疫到蛋白质和 RNA 降解系统的各个领域的 346 个新的 motif 实例。总共添加了 39 类新注释的 motif，数据库中还有 17 个现有条目进行了更新。2024 年的 ELM 版本现在包含 356 个 motif 类，其中包含手动整理自 4274 篇科学出版物的 4283 个 motif 实例，包括 700 多个与实验确定的 3D 结构的链接。最近的一个发展是，InterPro 蛋白质模块资源现在也包含 ELM 数据。ELM 可在以下网址获得：http://elm.eu.org。
