对宿主免疫应对肺囊虫的认识的新进展。
New advances in understanding the host immune response to Pneumocystis.
机构信息
Institute of Infectious Disease and Molecular Medicine (IDM), Department of Pathology, Faculty of Health Sciences, University of Cape Town, South Africa.
Center for Translational Research in Infection and Inflammation, Tulane School of Medicine, New Orleans, USA.
出版信息
Curr Opin Microbiol. 2017 Dec;40:65-71. doi: 10.1016/j.mib.2017.10.019. Epub 2017 Nov 12.
Abstract
Pneumocystis jirovecii causes clinical pneumonia in immunocompromised hosts. Despite this, the inability to cultivate this organism in vitro has likely hindered the field in ascertaining the true impact of Pneumocystis in human infection. However the recent release of the genome as well as in advances in understanding host genetics, and other risk factors for infection and robust experimental models of disease have shed new light on the impact of this fungal pathogen as to better define populations at risk. This review will highlight these recent advances as well as highlight future needed areas of research.
摘要
肺孢子菌引起免疫功能低下宿主的临床肺炎。尽管如此，由于无法在体外培养这种生物体，这可能阻碍了该领域确定肺孢子菌在人类感染中的真正影响。然而，最近基因组的发布以及对宿主遗传学和其他感染风险因素的深入了解，以及疾病的强大实验模型，为这种真菌病原体的影响提供了新的认识，从而更好地确定了处于危险中的人群。本文将重点介绍这些最新进展，并强调未来需要研究的领域。
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