生物-无机杂化系统作为化学产物的通用平台。
Biological-inorganic hybrid systems as a generalized platform for chemical production.
机构信息
Department of Systems Biology, Harvard Medical School, Harvard University, Boston, MA 02115, USA.
Department of Systems Biology, Harvard Medical School, Harvard University, Boston, MA 02115, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
出版信息
Curr Opin Chem Biol. 2017 Dec;41:107-113. doi: 10.1016/j.cbpa.2017.10.023. Epub 2017 Nov 12.
An expanding renewable energy market to supplant petrochemicals has motivated synthesis technologies that use renewable feedstocks, such as CO. Hybrid biological-inorganic systems provide a sustainable, efficient, versatile, and inexpensive chemical synthesis platform. These systems comprise biocompatible electrodes that transduce electrical energy either directly or indirectly into bioavailable energy, such as H and NAD(P)H. In combination, specific bacteria use these energetic reducing equivalents to fix CO into multi-carbon organic compounds. As hybrid biological-inorganic technologies have developed, the focus has shifted from phenomenological and proof-of-concept discovery towards enhanced energy efficiency, production rate, product scope, and industrial robustness. In this review, we highlight the progress and the state-of-the-art of this field and describe the advantages and challenges involved in designing bio- and chemo- compatible systems.
一个不断扩大的可再生能源市场，以取代石化产品，促使人们开发了使用可再生原料（如 CO）的合成技术。混合生物-无机系统提供了一个可持续、高效、多功能和廉价的化学合成平台。这些系统包括生物相容性电极，它们将电能直接或间接地转化为生物可用的能量，如 H 和 NAD(P)H。结合特定的细菌，这些能量还原当量将 CO 固定成多碳有机化合物。随着混合生物-无机技术的发展，人们的关注点已经从现象学和概念验证发现，转向提高能源效率、生产速率、产品范围和工业稳健性。在这篇综述中，我们强调了该领域的进展和现状，并描述了设计生物和化学相容系统所涉及的优势和挑战。
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