Department of Systems Biology, Harvard Medical School, Harvard University, Boston, MA 02115, USA.
Department of Systems Biology, Harvard Medical School, Harvard University, Boston, MA 02115, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Curr Opin Chem Biol. 2017 Dec;41:107-113. doi: 10.1016/j.cbpa.2017.10.023. Epub 2017 Nov 12.
An expanding renewable energy market to supplant petrochemicals has motivated synthesis technologies that use renewable feedstocks, such as CO. Hybrid biological-inorganic systems provide a sustainable, efficient, versatile, and inexpensive chemical synthesis platform. These systems comprise biocompatible electrodes that transduce electrical energy either directly or indirectly into bioavailable energy, such as H and NAD(P)H. In combination, specific bacteria use these energetic reducing equivalents to fix CO into multi-carbon organic compounds. As hybrid biological-inorganic technologies have developed, the focus has shifted from phenomenological and proof-of-concept discovery towards enhanced energy efficiency, production rate, product scope, and industrial robustness. In this review, we highlight the progress and the state-of-the-art of this field and describe the advantages and challenges involved in designing bio- and chemo- compatible systems.
一个不断扩大的可再生能源市场，以取代石化产品，促使人们开发了使用可再生原料（如 CO）的合成技术。混合生物-无机系统提供了一个可持续、高效、多功能和廉价的化学合成平台。这些系统包括生物相容性电极，它们将电能直接或间接地转化为生物可用的能量，如 H 和 NAD(P)H。结合特定的细菌，这些能量还原当量将 CO 固定成多碳有机化合物。随着混合生物-无机技术的发展，人们的关注点已经从现象学和概念验证发现，转向提高能源效率、生产速率、产品范围和工业稳健性。在这篇综述中，我们强调了该领域的进展和现状，并描述了设计生物和化学相容系统所涉及的优势和挑战。
