Wang Z B, An X J, Deng J F, Liu J H, Shi H Y
Department of Pathology, the Chinese PLA General Hospital, Beijing 100853, China.
Zhonghua Bing Li Xue Za Zhi. 2017 Nov 8;46(11):760-763. doi: 10.3760/cma.j.issn.0529-5807.2017.11.005.
To investigate the expression of ERG, Fli-1, CD34, CD31 and factor Ⅷ-related antigen(FⅧRAg) in hepatic malignant vascular tumors. A retrospective analysis was conducted on 63 cases of primary hepatic malignant vascular tumors and 31 cases of hepatic other malignant spindle cell tumors collected during January 1986 to January 2014. EnVision method was used to detect the expression of ERG, Fli-1, CD34, CD31, FⅧRAg. Sixty-three cases of malignant vascular tumors, including 24 cases of angiosarcoma, 38 cases of epithelioid hemangioendothelioma and 1 case of hepatic Kaposi's sarcoma. All of the cases were positive for ERG(100.0%, 63/63). Positive rate of Fli-1, CD34, CD31, FⅧRAg was 96.8% (61/63), 87.3% (55/63), 81.0% (51/63) and 41.3% (26/63), respectively. In other hepatic malignant spindle cell tumors, the positive rate of ERG, Fli-1, CD34, CD31 and FⅧRAg was 3.2% (1/31), 19.4% (6/31), 19.4% (6/31), 9.7%(3/31) and 3.2%(1/31), respectively.The sensitivity of ERG, Fli-1, CD34, CD31, FⅧRAg was 100.0%, 96.8%, 87.3%, 81.0% and 41.3%, respectively.The specificity was 96.8%, 80.6%, 80.6%, 90.3% and 96.8%, respectively. ERG is a more sensitive and specific diagnostic marker for hepatic malignant vascular tumors in comparison to Fli-1, CD34, CD31 and FⅧRAg.
研究ERG、Fli-1、CD34、CD31及因子Ⅷ相关抗原（FⅧRAg）在肝脏恶性血管肿瘤中的表达情况。对1986年1月至2014年1月期间收集的63例原发性肝脏恶性血管肿瘤及31例肝脏其他恶性梭形细胞瘤进行回顾性分析。采用EnVision法检测ERG、Fli-1、CD34、CD31、FⅧRAg的表达。63例恶性血管肿瘤中，包括24例血管肉瘤、38例上皮样血管内皮瘤及1例肝脏卡波西肉瘤。所有病例ERG均呈阳性（100.0%，63/63）。Fli-1、CD34、CD31、FⅧRAg的阳性率分别为96.8%（61/63）、87.3%（55/63）、81.0%（51/63）和41.3%（26/63）。在其他肝脏恶性梭形细胞瘤中，ERG、Fli-1、CD34、CD31及FⅧRAg的阳性率分别为3.2%（1/31）、19.4%（6/31）、19.4%（6/31）、9.7%（3/31）和3.2%（1/31）。ERG、Fli-1、CD34、CD31、FⅧRAg的敏感度分别为100.0%、96.8%、87.3%、81.0%和41.3%。特异度分别为96.8%、80.6%、80.6%、90.3%和96.8%。与Fli-1、CD34、CD31及FⅧRAg相比，ERG是肝脏恶性血管肿瘤更敏感、特异的诊断标志物。
