Molecular Toxicology Laboratory, Department of Biotechnology, Bharathiar University, Coimbatore 641 046, Tamilnadu, India.
Molecular Toxicology Laboratory, Department of Biotechnology, Bharathiar University, Coimbatore 641 046, Tamilnadu, India.
Biomed Pharmacother. 2018 Jan;97:928-940. doi: 10.1016/j.biopha.2017.10.164. Epub 2017 Nov 7.
During the past five decades, cancer cell lines are being successfully used as an in vitro model to discover the anti-cancer potential of plant secondary metabolites. Fisetin - the most popular polyphenol from fruits and vegetables, exhibits a repertoire of promising pharmacological features. Such versatile properties make fisetin an excellent anticancer agent and its efficacy as a chemotherapeutic agent against tumor heterogeneity from in vitro studies are encouraging. Fisetin is like a Pandora's box, as more research studies are being carried out, it reveals its new molecules within the cancer cells as therapeutic targets. These molecular targets orchestrate processes such as apoptosis, autophagic cell death, cell cycle, invasion, metastasis and angiogenesis in cancer cells. Besides apoptotic elicitation, fisetin's ability to induce autophagic cell death in cancer cells has been reported. This review examines the various molecular mechanisms of action elicited by fisetin leading to apoptosis and autophagic cell death as evidenced from cancer cell lines. In addition, the increased bioavailability and sustained release of fisetin improved through conjugation and enhanced effect of fisetin through synergism on various cancers are also highlighted.
在过去的五十年中，癌细胞系被成功地用作体外模型，以发现植物次生代谢物的抗癌潜力。漆黄素——一种来自水果和蔬菜的最受欢迎的多酚，具有一系列有前途的药理学特性。这种多功能特性使漆黄素成为一种极好的抗癌药物，其作为化学治疗剂对肿瘤异质性的疗效在体外研究中令人鼓舞。漆黄素就像一个潘多拉的盒子，随着更多的研究，它在癌细胞内揭示了新的分子作为治疗靶点。这些分子靶点协调细胞凋亡、自噬性细胞死亡、细胞周期、侵袭、转移和血管生成等过程。除了诱导细胞凋亡外，据报道，漆黄素还能诱导癌细胞发生自噬性细胞死亡。这篇综述检查了漆黄素通过诱导细胞凋亡和自噬性细胞死亡的各种分子机制，这些机制是从癌细胞系中得到的证据。此外，还强调了通过共轭提高漆黄素的生物利用度和持续释放，并通过协同作用增强漆黄素对各种癌症的效果。
