Zhao Yufan, Deng Shimenghui, Cao Danli, Lin Caiji, Xu Mengzhi, Wang Jiaxing, Luo Lingjie, Liu Shulin, Liu Huidi
Genomics Research Center (Key Laboratory of Gut Microbiota and Pharmacogenomics of Heilongjiang Province, State-Province Key Laboratory of Biomedicine-Pharmaceutics of China), College of Pharmacy, Harbin Medical University, Harbin 150081, China.
HMU-UCFM Centre for Infection & Genomics, Harbin Medical University, Harbin 150081, China.
Chin Herb Med. 2025 Apr 11;17(3):448-463. doi: 10.1016/j.chmed.2025.04.002. eCollection 2025 Jul.
Cancer is a highly deadly disease, with breast cancer, cervical cancer, endometrial cancer, and ovarian cancer being the most prevalent in women. However, traditional cancer treatments present challenges due to their strong toxic side effects and adverse reactions. Numerous studies have demonstrated that natural products derived from various plants possess therapeutic and preventive properties against cancer. These phytochemicals have been extensively investigated as a potential alternative to conventional chemotherapy drugs, owing to their safety and efficacy. This article provides a comprehensive review of the recent advances in the chemoprevention and mechanisms of phytochemicals against the four major female cancers. The focus will be on how these phytochemicals regulate cancer cell proliferation, apoptosis, invasion, and metastasis to impede cancer progression. Given their extensive clinical applications, phytochemicals hold great promise in the field of cancer treatment. It hopes that this review will inspire more researchers to explore the potential of these natural compounds in combating female cancers.
癌症是一种高致命性疾病,乳腺癌、宫颈癌、子宫内膜癌和卵巢癌在女性中最为常见。然而,传统的癌症治疗方法因其强烈的毒副作用和不良反应而面临挑战。大量研究表明,源自各种植物的天然产物具有抗癌治疗和预防特性。由于其安全性和有效性,这些植物化学物质已被广泛研究作为传统化疗药物的潜在替代品。本文全面综述了植物化学物质在预防这四种主要女性癌症方面的最新进展及其作用机制。重点将放在这些植物化学物质如何调节癌细胞的增殖、凋亡、侵袭和转移以阻碍癌症进展。鉴于其广泛的临床应用,植物化学物质在癌症治疗领域具有巨大潜力。希望这篇综述能激励更多研究人员探索这些天然化合物在对抗女性癌症方面的潜力。