Qaed Eskandar, Al-Hamyari Bandar, Al-Maamari Ahmed, Qaid Abdullah, Alademy Haneen, Almoiliqy Marwan, Munyemana Jean Claude, Al-Nusaif Murad, Alafifi Jameel, Alyafeai Eman, Safi Mohammed, Geng Zhaohong, Tang Zeyao, Ma Xiaodong
State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, People's Republic of China.
School of Pharmacy and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, People's Republic of China.
Glob Med Genet. 2023 Aug 9;10(3):205-220. doi: 10.1055/s-0043-1772219. eCollection 2023 Sep.
Cancer remains a critical global health challenge and a leading cause of mortality. Flavonoids found in fruits and vegetables have gained attention for their potential anti-cancer properties. Fisetin, abundantly present in strawberries, apples, onions, and other plant sources, has emerged as a promising candidate for cancer prevention. Epidemiological studies linking a diet rich in these foods to lower cancer risk have sparked extensive research on fisetin's efficacy. This review aims to comprehensively explore the molecular mechanisms of fisetin's anticancer properties and investigate its potential synergistic effects with other anticancer drugs. Furthermore, the review examines the therapeutic and preventive effects of fisetin against various cancers. A systematic analysis of the available scientific literature was conducted, including research articles, clinical trials, and review papers related to fisetin's anticancer properties. Reputable databases were searched, and selected studies were critically evaluated to extract essential information on fisetin's mechanisms of action and its interactions with other anticancer drugs. Preclinical trials have demonstrated that fisetin inhibits cancer cell growth through mechanisms such as cell cycle alteration, induction of apoptosis, and activation of the autophagy signaling pathway. Additionally, fisetin reduces reactive oxygen species levels, contributing to its overall anticancer potential. Investigation of its synergistic effects with other anticancer drugs suggests potential for combination therapies. Fisetin, a bioactive flavonoid abundant in fruits and vegetables, exhibits promising anticancer properties through multiple mechanisms of action. Preclinical trials provide a foundation for further exploration in human clinical trials. Understanding fisetin's molecular mechanisms is vital for developing novel, safe, and effective cancer prevention and treatment strategies. The potential synergy with other anticancer drugs opens new avenues for combination therapies, enhancing cancer management approaches and global health outcomes.
癌症仍然是一项严峻的全球健康挑战，也是主要的死亡原因。水果和蔬菜中发现的类黄酮因其潜在的抗癌特性而受到关注。富含于草莓、苹果、洋葱和其他植物来源中的漆黄素，已成为一种有前景的癌症预防候选物质。将富含这些食物的饮食与较低癌症风险联系起来的流行病学研究，引发了对漆黄素功效的广泛研究。 本综述旨在全面探索漆黄素抗癌特性的分子机制，并研究其与其他抗癌药物的潜在协同作用。此外，该综述还考察了漆黄素对各种癌症的治疗和预防作用。 对现有科学文献进行了系统分析，包括与漆黄素抗癌特性相关的研究文章、临床试验和综述论文。检索了知名数据库，并对所选研究进行了严格评估，以提取有关漆黄素作用机制及其与其他抗癌药物相互作用的重要信息。 临床前试验表明，漆黄素通过改变细胞周期、诱导细胞凋亡和激活自噬信号通路等机制抑制癌细胞生长。此外，漆黄素还降低了活性氧水平，这有助于其整体抗癌潜力。对其与其他抗癌药物协同作用的研究表明了联合治疗的潜力。 漆黄素是一种在水果和蔬菜中大量存在的生物活性类黄酮，通过多种作用机制展现出有前景的抗癌特性。临床前试验为在人类临床试验中的进一步探索奠定了基础。了解漆黄素的分子机制对于开发新颖、安全且有效的癌症预防和治疗策略至关重要。与其他抗癌药物的潜在协同作用为联合治疗开辟了新途径，增强了癌症管理方法和全球健康成果。
