Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Arasto Pharmaceutical Chemicals Inc., Yousefabad, Jahanarar Avenue, Tehran, Iran.
Talanta. 2018 Feb 1;178:704-709. doi: 10.1016/j.talanta.2017.10.001. Epub 2017 Oct 5.
Hierarchical leaf-like gold nanolayers were electrodeposited using choline chloride as a shape directing agent and characterized using field emission scanning electron microscopy. The electrooxidation behavior of vorinostat was then studied on the nanolayers and the kinetic parameters of the electrodic process were obtained by voltammetric measurements in a phosphate buffer solution at pH 7.40. Vorinostat was electrooxidized on the nanolayers' surface at a lower potential and with a higher rate, compared to a polycrystalline smooth gold surface, through an irreversible process. Based on the results, an amperometric sensor was designed using the hierarchical leaf-like gold nanolayers for the determination of vorinostat. A linear dynamic range of 4.0-52μmol L with a calibration sensitivity of 7.7mAmolL, and a detection limit of 1.40μmolL were obtained. The amperometry method was also applied to the analysis of vorinostat capsules.
采用氯化胆碱作为形状导向剂，通过电化学沉积制备了分层叶状金纳米层，并采用场发射扫描电子显微镜对其进行了表征。然后在纳米层上研究了伏立诺他的电氧化行为，并通过在 pH 值为 7.40 的磷酸盐缓冲溶液中的伏安测量获得了电化学反应过程的动力学参数。与多晶光滑金表面相比，伏立诺他在纳米层表面以较低的电位和更高的速率发生不可逆电氧化。基于这些结果，使用分层叶状金纳米层设计了一种用于测定伏立诺他的安培传感器。获得了 4.0-52μmol L 的线性动态范围，校准灵敏度为 7.7mAmolL，检测限为 1.40μmolL。该安培法还应用于伏立诺他胶囊的分析。
