Rong Hao, He Xue, Wang Li, He Yongjun, Kang Longli, Jin Tianbo
Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China.
Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China.
Oncotarget. 2017 Jun 9;8(47):82078-82084. doi: 10.18632/oncotarget.18427. eCollection 2017 Oct 10.
Renal cell carcinoma (RCC) is considered to be a kind of cytokine reactive tumor. The research has been suggested that the host immune system can regulate the clinical course of RCC. Therefore, cytokine gene polymorphisms in RCC patients were analyzed was necessary. Our study is purpose to analyzing the interleukin-4(IL-4) polymorphisms associated with RCC risk from Han Chinese population. IL-4 genetic polymorphisms were genotyped using Massarray technology from a total of 291RCC and 463 controls. Unconditional logistic regression analysis was performed to analyze their relationship with risk of RCC. A significant association was found between the rs2243250 "C" allel and decreased risk of RCC (OR=0.75, 95%CI=0.59-0.96, P=0.02). Stratified analysis based on the age, gender, smoking status, drinking status revealed no significant association with RCC in age>55, female, smoking and nodrinking. However, for age<55 group (rs2243250, rs2243267, rs2243270), male group (rs2243250), nonsmoking group (rs2227284), and drinking group (rs2243250, rs2227284, rs2243267, rs2243270) polymorphisms were found obviously associated with RCC. The haplotype analyses showed that the haplotype have a significant decreased risk of RCC in the rs2243250/rs2227284/rs2243267/rs2243270/rs2243283/rs2243289 (CGGACA) (Total, OR=0.73, 95%CI=0.54-0.98, P=0.034; Male, OR=0.59, 95%CI=0.39-0.90, P=0.014). Therefore, the present study suggests that IL-4 may be a candidate gene for assessing the risk of RCC.
肾细胞癌（RCC）被认为是一种细胞因子反应性肿瘤。已有研究表明，宿主免疫系统可调节RCC的临床进程。因此，分析RCC患者的细胞因子基因多态性很有必要。我们的研究旨在分析汉族人群中与RCC风险相关的白细胞介素-4（IL-4）多态性。采用Massarray技术对291例RCC患者和463例对照进行IL-4基因多态性基因分型。进行非条件逻辑回归分析以分析它们与RCC风险的关系。发现rs2243250 “C” 等位基因与RCC风险降低显著相关（OR=0.75，95%CI=0.59-0.96，P=0.02）。基于年龄、性别、吸烟状况、饮酒状况的分层分析显示，在年龄>55岁、女性、吸烟和不饮酒者中与RCC无显著关联。然而，对于年龄<55岁组（rs2243250、rs2243267、rs2243270）、男性组（rs2243250）、非吸烟组（rs2227284）和饮酒组（rs2243250、rs2227284、rs2243267、rs2243270），发现多态性与RCC明显相关。单倍型分析表明，在rs2243250/rs2227284/rs2243267/rs2243270/rs2243283/rs2243289（CGGACA）中，单倍型使RCC风险显著降低（总体，OR=0.73，95%CI=0.54-0.98，P=0.034；男性，OR=0.59，95%CI=0.39-0.90，P=0.014）。因此，本研究表明IL-4可能是评估RCC风险的候选基因。
