Microfluidics Fabrication of Self-Oscillating Microgel Clusters with Tailored Temperature-Responsive Properties Using Polymersomes as "Microreactors".

Poly(N-isopropylacrylamide)-based microgel clusters were successfully prepared using polymersomes as "microreactors", which were fabricated through microfluidics. The clusters were formed from the cross-linking reaction between ruthenium/amino group dual functionalized poly(N-isopropylacrylamide) microgels and linear poly(N-isopropylacrylamide)-r-(N-acryloxysuccinimide)-based polymer linkers under neutral pH conditions. By simply adjusting the ratio of N-isopropylacrylamide to N-acryloxysuccinimide in the polymer cross-linkers, the internal structures of the clusters can be controlled; hence, the temperature response of the clusters can be regulated. It was demonstrated that these different microgel clusters showed various degrees of chemomechanical oscillations when the clusters were exposed to a catalyst-free solution containing Belousov-Zhabotinsky reaction substrates.