Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Vietnam
Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
Biosci Rep. 2017 Dec 15;37(6). doi: 10.1042/BSR20171270. Print 2017 Dec 22.
Sterol regulatory element binding protein 1c (SREBP-1c) promotes lipogenesis and tumor growth in various cancers. It is well known that clear cell renal cell carcinoma (ccRCC), a major subtype of the kidney cancers, exhibits elevated lipid accumulation. However, it has not been fully understood how lipid metabolism might be associated with cell cycle regulation in ccRCC. In a recent issue, Lee et al. (Molecular and Cellular Biology (2017) pii: MCB.00265-17) demonstrate that SREBP-1c is up-regulated in ccRCC by ring finger protein 20 (RNF20) down-regulation, leading to aberrant lipid storage and pituitary tumor transforming gene 1 ()-dependent cell cycle progression. These findings suggest that SREBP-1c serves as a molecular bridge between lipid metabolism and cell cycle control in ccRCC tumorigenesis.
固醇调节元件结合蛋白 1c（SREBP-1c）促进多种癌症中的脂肪生成和肿瘤生长。众所周知，肾透明细胞癌（ccRCC）是肾脏癌的主要亚型，表现出脂质蓄积增加。然而，尚不完全清楚脂质代谢如何与 ccRCC 中的细胞周期调控相关。在最近一期的《分子和细胞生物学》（2017 年，pii：MCB.00265-17）中，Lee 等人证明，RNF20 下调导致 SREBP-1c 在 ccRCC 中上调，导致异常脂质储存和垂体肿瘤转化基因 1（PTTG1）依赖性细胞周期进程。这些发现表明，SREBP-1c 在 ccRCC 肿瘤发生中作为脂质代谢和细胞周期控制之间的分子桥梁。
