Faculty of Nursing, Tokai University School of Medicine, Isehara, Kanagawa 259-1292, Japan.
Graduate School of Sports Sciences, Waseda University, Tokorozawa, Saitama 359-1192, Japan.
Medicina (Kaunas). 2019 Sep 15;55(9):594. doi: 10.3390/medicina55090594.
Aroma therapy is a complementary therapy using essential oils diluted with carrier oils. Jojoba oils have been widely used as carrier oils. However, limited information is available regarding their effects on blood biochemical parameters. This study aimed to investigate the effect of transdermal administration of jojoba oil on blood biochemical parameters in mice. Eight-week-old male hairless mice were randomly divided into naïve control and treatment groups. In the treatment group, mice were topically administered 4 μL of jojoba oil, per gram of body weight, on the dorsa 30 min before euthanasia. Thereafter, serum biochemical parameters were assayed, and gene expression was analyzed in various tissues via a real-time polymerase chain reaction. Serum non-esterified fatty acid (NEFA) levels increased significantly 30 min after topical application of jojoba oil ( < 0.05). was significantly upregulated in the liver ( < 0.05), and upregulation in the liver was positively correlated with serum NEFA levels ( = 0.592, < 0.05). Furthermore, a trend of decreasing fatty acid trafficking-related gene (, , , and ) expression in the skin after topical application of jojoba oil ( = 0.067, 0.074, 0.076, and 0.082, respectively) was observed. Serum NEFA levels were elevated 30 min after transdermal administration of jojoba oil. The mechanisms of elevated serum NEFA levels might be related to both enhanced lipolysis in the liver and reduced fatty acid trafficking in the skin.
香薰疗法是一种使用经过稀释的基础油调配的精油进行的补充疗法。霍霍巴油已被广泛用作基础油。然而，关于其对血液生化参数的影响，信息有限。本研究旨在探讨经皮给予霍霍巴油对小鼠血液生化参数的影响。
将 8 周龄雄性无毛小鼠随机分为空白对照组和治疗组。治疗组小鼠在处死前 30 分钟，于背部每克体重经皮给予 4 μL 霍霍巴油。然后测定血清生化参数，并通过实时聚合酶链反应分析各种组织中的基因表达。
霍霍巴油经皮给药 30 分钟后，血清非酯化脂肪酸（NEFA）水平显著升高（<0.05）。肝脏中 基因表达显著上调（<0.05），且肝脏中基因表达上调与血清 NEFA 水平呈正相关（=0.592，<0.05）。此外，霍霍巴油经皮给药后皮肤中脂肪酸转运相关基因（、、、和）表达呈下降趋势（=0.067、0.074、0.076、0.082，分别）。
霍霍巴油经皮给药 30 分钟后血清 NEFA 水平升高。血清 NEFA 水平升高的机制可能与肝脏中脂肪分解增强和皮肤中脂肪酸转运减少有关。
