Jenkins Blair A, Lumpkin Ellen A
Department of Physiology & Cellular Biophysics and Department of Dermatology, Columbia University in the City of New York, New York, NY 10032, USA.
Department of Physiology & Cellular Biophysics and Department of Dermatology, Columbia University in the City of New York, New York, NY 10032, USA
Development. 2017 Nov 15;144(22):4078-4090. doi: 10.1242/dev.120402.
The sensation of touch is mediated by mechanosensory neurons that are embedded in skin and relay signals from the periphery to the central nervous system. During embryogenesis, axons elongate from these neurons to make contact with the developing skin. Concurrently, the epithelium of skin transforms from a homogeneous tissue into a heterogeneous organ that is made up of distinct layers and microdomains. Throughout this process, each neuronal terminal must form connections with an appropriate skin region to serve its function. This Review presents current knowledge of the development of the sensory microdomains in mammalian skin and the mechanosensory neurons that innervate them.
触觉由嵌入皮肤的机械感觉神经元介导，这些神经元将外周信号传递至中枢神经系统。在胚胎发育过程中，轴突从这些神经元延伸出来，与发育中的皮肤建立联系。同时，皮肤上皮从一种均质组织转变为由不同层和微区组成的异质器官。在整个过程中，每个神经元末梢必须与适当的皮肤区域形成连接以发挥其功能。本综述介绍了哺乳动物皮肤感觉微区以及支配它们的机械感觉神经元发育的当前知识。
